Novel 2-aryl-3,4,5-trihydroxypiperidines： Synthesis and glycosidase inhibition-中国期刊网

摘要 Threepairsofnovel2-aryl-3,4,5-trihydroxypiperidines(6–8andtheirenantiomers),thepiperidineanaloguesofthepyrrolidinealkaloidsradicamineAandradicamineB,werepreparedfromsixmemberedcyclicnitronesthroughaconcisetwo-stepprocedure,i.e.,Grignardreagentadditionanddeprotection.Thesenovelpolyhydroxylatedpiperidineiminosugarswereassayedagainst10typesofenzymes.Onlycompound8exhibitedweakinhibition(IC501080mmol/L)againstb-galactosidasefromratintestinallactases.

1ZHANG Li-dan;HAN Chun-ying;FENG Xiu-ling;WEI Yong-ge;GUO Hong-you. Synthesis of Novel Quaternary Selenide K2CdSnSe4.化学,2010-04.
2. SYNTHESIS OF 3-ARYL-1(2H, 4H) ACRIDONES AND THEIR DERIVATIVES.化学,1994-12.
3A.Kavros W.H.Lang 等. SYNTHESIS OF ARYL FUNCTIONAL OLIGOMERS.高分子化学,2000-12.
4ZHANG，Yan;WANG，Qin;等. Synthesis and Antibacterial Activities of 4—Amino—3—（1—aryl—5—methyl—1,2,3—triazol—4—yl）—5—mercapto—1,2,4—triazoles／2—Amino—5—（1—aryl—5—methyl—1,2,3—triazol—4—yl）—1,3,4—.化学,2002-02.
5张慧;曹卫国;陈杰;胡吉嵘;钱嘉贤;朱士正. Highly Stereoselective Synthesis of trans-3-Aryl-4-carbethoxy-2,3-dihydro-2-fur-2＇-oyl-5-methylfurans.化学,2007-07.
6. A STUDY OF ACYLATION OF AN ENAMINE AND A NOVEL SYNTHESIS OF 4-PYRONES.化学,1992-05.
7CHENZuxing ZHANGZhaojun 等. SYNTHESIS OF N—ARYL—N‘—（4—hydroxy—BENZOYL）—THIOUREA DERIVATIVES USING PEG—SUPPORT.高分子化学,2000-05.
8Zhi Qiang Shi;Ya Qing Feng;Shu Xian Meng. Novel synthesis of N-substituted-calix[4]azacrown derivatives.化学,2010-07.
9Ying Fu Huai Yuan Zhang Yan Hua Liu Xue Feng Li Dan Feng Huang Yu Lai Hu. Synthesis of O-glycosylα-aryl nitrones.化学,2010-09.
10Meng Gao Cui Fen Lu Gui Chun Yang Zu Xing Chen. A novel approach for synthesis of 3-amino-5-aryl-2,5- dihydropyridazines using onium salt as soluble support.化学,2011-07.

Novel 2-aryl-3,4,5-trihydroxypiperidines： Synthesis and glycosidase inhibition

来源期刊

相关推荐

同分类资源更多

相关关键词

Novel 2-aryl-3,4,5-trihydroxypiperidines： Synthesis and glycosidase inhibition

来源期刊

相关推荐

同分类资源 更多

相关关键词

同分类资源更多