摘要
Gutmicrobiotaareinvolvedinthedevelopmentorpreventionofvariousdiseasessuchastype2diabetes,fattyliver,andmalignancysuchascolorectalcancer,breastcancerandhepatocellularcarcinoma.Alzheimer’sdisease,osteoporosis,sarcopenia,atheroscleroticstrokeandcardiovasculardiseasearemajordiseasesassociatedwithdecreasedactivitiesofdailyliving(ADL),especiallyinelderlypeople.Recentanalyseshaverevealedtheimportanceofgutmicrobiotainthecontrolofthesediseases.Thecompositionordiversityofthesemicrobiotaisdifferentbetweenpatientswiththeseconditionsandhealthycontrols,andadministrationofprobioticsorprebioticshasbeenshowneffectiveinthetreatmentofthesediseases.Gutmicrobiotamayaffectdistantorgansthroughmechanismsthatincluderegulatingtheabsorptionofnutrientsand/ortheproductionofmicrobialmetabolites,regulatingandinteractingwiththesystemicimmunesystem,andtranslocatingbacteria/bacterialproductsthroughdisruptedmucosalbarriers.Thus,thegutmicrobiotamaybeimportantregulatorsinthedevelopmentofdiseasesthataffectADL.Althoughadequateexerciseandproperdietareimportantforpreventingthesediseases,theircombinationwithinterventionsthatmanipulatethecompositionand/ordiversityofgutmicrobiotacouldbeapromisingstrategyformaintaininghealthconditionandpreservingADL.ThisreviewthussummarizescurrentunderstandingoftheroleofgutmicrobiotainthedevelopmentorpreventionofdiseasescloselyassociatedwiththemaintenanceofADL.
出版日期
2018年12月22日（中国期刊网平台首次上网日期，不代表论文的发表时间）
