摘要
AIM:Toinvestigatethefactorsinfluencingtheoccurrenceofgastricvarioliformlesions(GVLs)andtheirpossiblelinkwithgastriccancer.METHODS:A1:1matchedcase-controlstudywasperformedtoretrospectivelyanalyzedatafrom1638chronicgastritispatientswhohadundergonegastroscopyatoneoftwoChinesehospitalsbetween2009and2014.PatientswithGVLs(cases)werecomparedtothosewithoutsuchlesions(controls).Endoscopicandpathologicalfindingswererecorded,alongwithinterviewinformationonHelicobacterpylori(H.pylori)infection,medical,drugandfamilyhistories,lifestyleandeatinghabits.TheassociationbetweeneachfactorandtheoccurrenceofGVLswasestimated,andthenmultivariateconditionallogisticregressionwasusedtoevaluatetheindependentfactors.RESULTS:Thefrequencyandseverityofglandularatrophy,intestinalmetaplasia(IM)andlow-gradeintraepithelialneoplasiaweresignificantlyincreasedintheGVLgroup(P<0.01).OverallanalysisshowedthatH.pyloriinfection[3.051(2.157,4.317),P<0.001],allergicrespiratorydiseases[3.636(2.183,6.055),P<0.001],work-relatedstress[2.019(1.568,2.600),P<0.001],irregularmeals[2.300(1.462,3.619),P<0.001],highintakeofspicyfood[1.754(1.227,2.507),P=0.002]andhighintakeoffreshfruit[0.231(0.101,0.529),P=0.001]weresignificantlycorrelatedwiththeoccurrenceofGVLs(positively,exceptforthelatter).Stratifiedanalysesindicatedthatpickledfoodconsumptioninpatientsover50yearsold[7.224(2.360,22.115),P=0.001]andexcessivesmokinginmen[2.013(1.282,3.163),P=0.002]werealsopositivelycorrelated,andthat,forantralGVLs,vegetableconsumption[0.491(0.311,0.776),P=0.002]wasnegativelycorrelated.CONCLUSION:SevenriskfactorsandtwoprotectivefactorsaredeterminedforGVLs,whichwerefoundtobeassociatedwithpremalignantabnormalities.
出版日期
2016年12月22日（中国期刊网平台首次上网日期，不代表论文的发表时间）
