摘要
Objective:Toobservethelong-termeffectofhomoharringtonine(HHT)onchronicgranulocyticleukemia(CGL)anditspharmacologicalmechanism.Methods:76patientswithnewlydiagnosedearlychronicphaseCGLreceivedtreatmentofmerely1.5mg/m2dailyHHTforinductionremissionandlong-termmaintenancetreatment.TheapoptosisrateofbonemarrowCD34+cellsinducedbyHHTwasassayedwithflowcytometer.Results:86.8%patientsachievedCHR,13.2%patientsPHRand31.8%patientsgotcytogeneticresponseinHHTtreatmentgroup,whichwaslongerthan31(8-54)monthsinhydroxyurea(HU)group(P<0.05).TheeffectofapoptosisinductionHHTwasstrongeronCGL-CPpatientsbonemarrowCD34+cellsthanonnormalpersonbonemarrowCD34+cells.Conclusion:HHTisaveryeffectivedrugforremissioninductionandlong-termmaintenancetreatmentinearlychronicphaseCGLpatients.
出版日期
2005年02月12日(中国期刊网平台首次上网日期,不代表论文的发表时间)