简介:GenemodificationoftumorcellstoexpressavarietyofcytokinessuchasIL-2ortheco-stimulatorymoleculeB7.1ledtoincreasedimmunogenicityandreducedtumorigenicityoftumorshasseveralmodelsandthisprocessinvolvesTcells.WehavepreviouslyreporteddecreasedtumorigenicityofthemurineplasmacytomaJ558L(MHCclassⅠ~+andclassⅡ~-)expressingIL-2orB7.l.Whensystemicimmunitywasanalyzed,