简介:目的:分析复方血塞通联合康柏西普对病理性近视脉络膜新生血管(choroidalneovascularization,CNV)患者黄斑中心视网膜厚度(centralmacularretinalthickness,CMT)、荧光素眼底血管造影及最佳矫正视力(BCVA)的影响。方法:根据不同治疗方法将60例60眼病理性CNV患者分为观察组(复方血塞通联合康柏西普治疗)与对照组(单纯康柏西普治疗),各30例,比较两组患者治疗前后CMT、眼压(IOP)、CNV面积、BCVA及血清中血管内皮生长因子(VEGF)变化情况,统计随访期间并发症情况。结果:观察组术后12wk视力恢复总有效率(97%)显著高于对照组的80%,差异有统计学意义(P〈0.05);与术前比较,两组患者术后12wk时CMT、IOP、CNV面积及血清VEGF水平均显著下降,BCVA显著提高,差异有统计学意义(P〈0.01),且观察组术后上述指标均明显优于对照组,差异有统计学意义(P〈0.01)。两组患者均无局部并发症及全身严重并发症发生。结论:复方血塞通联合康柏西普能有效降低CMT及IOP,缩小CNV面积,显著提高视力。
简介:目的探讨用冲洗式泪道探通联合左氧氟沙星眼用凝胶注入术治疗新生儿泪囊炎的临床效果。方法对2009年我院眼科门诊就诊并记录的38例46眼新生儿泪囊炎患儿,首先使用泪囊区挤压按摩及泪道加压冲洗法治疗,未愈者继而使用冲洗式泪道探通联合左氧氟沙星眼用凝胶注入术,术中左氧氟沙星眼用凝胶充满泪囊,术后追踪随访并观察疗效。结果46眼均经过泪囊区挤压按摩及泪道加压冲洗治疗,治愈17眼,治愈率为36.96%;29眼行冲洗式泪道探通联合左氧氟沙星眼用凝胶注入术治愈28眼,治愈率为96.55%;无效1眼。结论对于用常规方法不能治愈的新生儿泪囊炎,选用冲洗式泪道探通联合左氧氟沙星眼用凝胶注入术的临床疗效是肯定的,值得临床推广。
简介:AIM:Tocomparetheeffectoftopicallyadministeredandsubconjunctivallyinjectedbevacizumabonexperimentalcornealneovascularizationinratsfortwoweeksaftertreatment.METHODS:Twenty-eightSprague-Dawleyratsweredividedintofourgroupsof7animals.Eachcornealcenterofrighteyewascauterizedwithsilver/potassiumnitratefor8s.Aftercornealburning,bevacizumab(12.5mg/mL)wastopicallyadministeredthreetimesperday(TBgroup)fortwoweeksorsubconjunctivallyinjectedondays2and4aftercauterization(0.02mL;SBgroup).Asnegativecontrols,ratsreceived0.9%salinetopicallythreetimesperday(TSgroup)orsubconjunctivallyondays2and4(0.02mL;SSgroup).Digitalphotographsofthecorneaweretaken1and2weeksaftertreatmentandanalyzedtodeterminetheareaofcorneacoveredbyneovascularizationasthepercentageofcornealneovascularization.RESULTS:Oneweekaftertreatment,thepercentageofcornealneovascularizationwassignificantlylowerintheTBandSBgroupsthanintheTSandSSgroups(allP<0.05).Twoweeksaftertreatment,thepercentageofcornealneovascularizationwassignificantlylowerintheTBgroupthanintheTSgroup(P<0.05).Inallgroups,thepercentageofneovascularizationwasdecreasingastimepassed(allP<0.05)CONCLUSION:Topicallyadministeredbevacizumabhaslongerstandinganti-angiogeniceffectthansubconjunctivallyinjectedbevacizumabincornealneovascularizationfollowingchemicalinjuryinrats.