简介：外文期刊刊名缩写是国际上一个通行的做法，要求采用美国国立图出馆编印的“IndexMedicus”中列出的缩写形式。鉴于作者来稿中外文期刊缩写混乱现象，特归纳刊名缩写时应遵循的几项原则。供作者参考。

简介：随着现代医学科学技术日新月异地不断发展,医学专业越分越细,学术期刊的种类也在不断增多,而外文期刊作为特定类型的出版物,具有内容广泛、知识新颖、出版周期短、情报含量大的特点,是临床医务人员了解世界医学动态的窗口,是促进医疗、教学、科研发展不可缺少的信息物.作为学习和借鉴世界先进医疗技术水平的主要工具,合理有效地管理好外文期刊,是为临床实行优质服务的重要前提,我院图书室加强了对外文期刊的管理,提高了外文期刊的利用效果.具体方法如下.

简介：目的:了解高影响因子肿瘤学外文期刊发表的口腔肿瘤学论文情况,为我国口腔肿瘤研究人员的论文投稿提供参考信息.方法:对2002年影响因子在1.000以上的肿瘤学外文期刊近5年(1998～2002年)发表的口腔肿瘤学论文进行检索分析.结果:共有40种影响因子在1.000以上的外文期刊发表了5篇以上口腔肿瘤学论文.结论:我国口腔肿瘤研究人员应深入了解这些期刊及所发表的口腔肿瘤学研究论文的特点,并有针对性地向高影响因子肿瘤学外文期刊投稿.

简介：Changesinneurocognitivefunctioningandqualityoflifeinadultpatientswithbraintumorstreatedwithradiotherapy.

简介：PURPOSE：Vorinostat,ahistonedeacetylaseinhibitor,representsarationaltherapeutictargetinglioblastomamultiforme（GBM）.PATIENTSANDMETHODS：PatientswithrecurrentGBMwhohadreceivedoneorfewerchemotherapyregimensforprogressivediseasewereeligible.

简介：Markedresponseofgliomatosiscerebritotemozolomideandwholebrainradiotherapy.

简介：PURPOSE：ResistancetotemozolomidechemotherapyispartlymediatedbyO^6-methylguanine-DNAmethlytransferase（MGMT）.ProtractedtreatmentwithtemozolomidepotentiallyovercomesMGMTresistanceandimprovesoutcome.WeconductedaphaseIIstudyofprotracteddailytemozolomideinadultswithlow-gradegliomas.EXPERIMENTALDESIGN：PatientswithnewlydiagnosedoligodendrogliomaoroligoastrocytomawithaMIB-1indexof〉5%orrecurrentlow-gradegliomasreceivedtemozolomide（75mg/m^2/dayin11-weekcyclesof7weekson/4weeksoff）.Treatmentcontinuedforatotalofsixcyclesoruntiltumorprogressionorunacceptabletoxicity.Primaryendpointwasbestoverallresponserate;secondaryendpointswereprogression-freesurvival,overallsurvival,andtoxicity.

简介：BACKGROUND：In2004,arandomisedphaseⅢtrialbytheEuropeanOrganisationforResearchandTreatmentofCancer（EORTC）andNationalCancerInstituteofCanadaClinicalTrialsGroup（NCIC）reportedimprovedmedianand2-yearsurvivalforpatientswithglioblastomatreatedwithconcomitantandadjuvanttemozolomideandradiotherapy.We＇reportthefinalresultswithamedianfollow-upofmorethan5years.METHODS：Adultpatientswithnewlydiagnosedglioblastomawererandomlyassignedtoreceiveeitherstandardradiotherapyoridenticalradiotherapywithconcomitanttemozolomidefollowedbyuptosixcyclesofadjuvanttemozolomide.

简介：Monochromaticminibeamsradiotherapy：fromhealthytissue-sparingeffectstudiestowardfirstexperimentalgliomabearingratstherapy.

简介：PURPOSE：Toevaluatethetoxicityandresponserateofbortezomibwithconcurrentradiotherapyandtemozolomideinthetreatmentofpatientswithcentralnervoussystemmalignancies.PATIENTSANDMETHODS：Thisopen-label,dose-escalation,PhaseⅠclinicalstudyevaluatedthesafetyofthreedoselevelsofintravenouslyadministeredbortezomib（0.7,1.0,and1.3mg/m（2）/dose）onDays1,4,8,and11ofa21-daycycle,inadditiontoconcurrentradiotherapyandtemozolomideatadailydoseof75mg/m（2）startingonDay1.Theprimaryendpointwasdose-limitingtoxicity,definedasanyGrade4-5toxicityorGrade3toxicitydirectlyat-tr/butabletoprotocoltreatment,requiringhospitalizationand/orradiotherapyinterruption.

简介：PURPOSE：ThisphaseⅡtrialwasdesignedtodefinetheroleofO^6-benzylguanine（O^6-BG）inrestoringtemozolomidesensitivityinpatientswithrecurrentorprogressive,temozolomidc-resistantmalignantgliomaandtoevaluatethesafetyofadministeringO^6-BGincombinationwithtemozolomide.PATIENTSANDMETHODS：Patientswereaccruedintotwoindependentstrataonthebasisofhistology：glioblastomamultifonne（GBM）andaanaplasticglioma.BothtemozolomideandO6-BGwereadministeredonday1ofa28-daytreatmentcycle.Patientswereadministereda1-hourO^6-BGinfusionatadoseof120mg/m^2followedimmediatelybya48-hourinfusionatadoseof30mg/m^2/d.

简介：PURPOSE：Toevaluatesingle-agentactivityofbevacizumabinpatientswithrecurrentglioblastoma.PATIENTSANDMETH-ODS：Patientswithrecurrentglioblastomaweretreatedwithbevacizumab10mg/kgevery2weeks.Aftertumorprogression,patientswereimmediatelytreatedwithbevacizumabincombinationwithirinotecan340mg/m^2or125mg/m^2every2weeks,dependingonuseofenzyme-inducingantiepilepticdrugs.Completepatientevaluationswererepeatedevery4weeks.RESULTS：Forty-eightheavilypretreatedpatientswereaccruedtothisstudy.Thromboembolicevents（12.5%）,hypertension（12.5%）,hypophosphatemia（6%）,andthrombocytopenia（6%）werethemostcommondrug-associatedadverseevents.Sixpatients（12.5%）wereremovedfromstudyfordrug-associatedtoxicity（fivethromboembolicevents,onebowelperforation）.

简介：

简介：PURPOSE：Fotemustineisanitrosoureacompoundusedforthetreatmentofmalignantgliomas,especiallyinFrance.Recently,anEORTC-NCICstudyhasshownthataconcomitantcombinationofradiotherapyplustemozolomide（anoralcytotoxicdrug）improvedsurvivalinglioblastomapatients.Wesetouttotestaconcurrentcombinationofradiotherapyandfotemustinefornewlymalignantgliomas.

简介：BACKGROUND：SupratentorialPNET（sPNET）arerareCNStumorsofembryonaloriginarisinginchildrenandadults.Thetreat-mentofsPNETforallagegroupsatourcancercenterhasbeenbasedonthemanagementofmedulloblastoma（MB）,involvingneurosurgicaldebulkingfollowedbyeranio-spinalirradiation（CS1）andsystemicchemotherapy.METHODS：MedicalrecordswerereviewedtogatherdemographicandclinicaldataaboutallembryonalCNStumorsinchildrenandadultsfrom2001to2007.Tumorpathology,clinicalmanagementandsurvivaldatawerealsoassessed,particularlyasregardsthosepatientswhoreceivedthePackerchemotherapyregimenforeithersPNETorMB.

简介：Humanglioblastomas(GBM)arethoughttobeinitiatedbygliomastem-likecells(GSLCs).GSLCsalsoparticipateintumorneovascularizationbytransdifferentiatingintovascularendothelialcells.Here,wereportacriticalroleofGSLCsintheformationofvasculogenicmimicry(VM),whichdefineschannelslinedbytumorcellstosupplynutrientstoearlygrowingtumorsandtumor

简介：Glioblastomaisoneofthemostangiogenichumantumorsandcharacterizedbymicrovascularproliferations.Abetterunderstandingofglioblastomavasculatureisneededtooptimizeanti-angiogenictherapythathasshownapromisingbutincompleteefficacy.Thepresentstudyexamined48glioblastomasbyCD34endothelialmarkerperiodicacid-Schiff(PAS)dualstainingandfoundnon-endothelialcell-linedblood

简介：RoleofEarlyPostradiationMagneticResonanceImagingScansinChildrenwithDiffuseIntrinsicPontineGlioma.

简介：Prophylacticantiepilepticdrugtherapyinpatientsundergoingsupratentorialmeningiomaresection：asystematicanalysisofefficacy.JNeurosurg.2011Jun3.[Epubaheadofprint]KomotarRJ,RaperDM,StarkeRM,IorgulescuJB,GutinPH.

简介：<正>InvitrobiologicaldosimetermodelingoftheglioblastomaresponsetoradiationdeliveredbytheGammaKnife.Laboratoryinvestigation.JNeurosurg.2010Dec;113Suppl:222-7.SmithR,SmithKA,BiggsCA,ScheckAC.Neuro-OncologyandNeurosurgeryResearch,BarrowNeurologicalInstitute,Phoenix,Arizona85013,USA.