简介:Objective:TheresultsofapreviousstudyshowedthatacleardysregulationwasevidentintheglobalgeneexpressionoftheBCL11A-suppressedB-lymphomacells.Inthisstudy,thebonemorphogeneticproteinreceptor,typeII(BMPR2),E1Abindingproteinp300(EP300),transforminggrowthfactor-β2(TGFβ2),andtumornecrosisfactor,andalpha-inducedprotein3(TNFAIP3)geneexpressionpatternsinB-cellmalignancieswerestudied.Methods:TherelativeexpressionlevelsofBMPR2,EP300,TGFβ2,andTNFAIP3mRNAinB-lymphomacelllines,myeloidcelllines,aswellasincellsfromhealthyvolunteers,weredeterminedbyreal-timequantitativereversetranscriptpolymerasechainreaction(qRT-PCR)withSYBRGreenDye.Glyceraldehyde-3-phosphatedehydrogenase(GAPDH)wasusedasreference.Results:TheexpressionlevelofTGFβ2mRNAinB-lymphomacelllineswassignificantlyhigherthanthoseinthecellsfromthehealthycontrol(P<0.05).However,theexpressionlevelofTNFAIP3mRNAinB-malignantcellswassignificantlylowerthanthatofthehealthycontrol(P<0.05).TheexpressionlevelsofBMPR2andEP300mRNAshowednosignificantdifferencebetweenB-malignantcelllinesandthehealthygroup(P>0.05).InB-lymphomacelllines,correlationanalysesrevealedthattheexpressionofBMPR2andTNFAIP3(r=0.882,P=0.04)hadsignificantpositiverelation.TheexpressionlevelsofBMPR2,EP300,andTNFAIP3mRNAincelllinesfrommyeloidleukemiaweresignificantlylowerthanthoseinthecellsfromthehealthycontrol(P<0.05).TheexpressionlevelsofTGFβ2mRNAshowednosignificantdifferencebetweenmyeloidleukemiacelllinesandthehealthycontrolorB-malignantcelllines(P>0.05).TheexpressionlevelsofBMPR2,EP300,andTNFAIP3mRNAinB-lymphomacellsweresignificantlyhigherthanthoseofthemyeloidleukemiacells(P<0.05).Conclusion:DifferentexpressionpatternsofBMPR2,EP300,TGFβ2,andTNFAIP3genesinB-lymphomacellsexist.更多还原
简介:ThefourthilnternationalExhibi-tiononEnergy(power)(EPChina’92heldfromMay19to24,1992wassuccessfullyconcluded.ExhibitsattheEx-hibitioncomefrom280factoriesandcom-panies,researchinstitutesanduniversitiesofthe10EECmembercountries,Australia,Canada,Norway,theUnitedStates,Japan
简介:摘要:机器人编程教学作为当今时代重要的人工智能教育方向之一,正越来越受到人们的关注。深入研究机器人编程教学实践对于推进人工智能教育、培养学生创新思维与解决问题的能力具有重要的意义。本文将以EP机器人编程教学实践研究为主题,探究机器人编程教学实践中教学设计、教学模式、教学评价等方面的问题。
简介:摘要:目的:分析宫腔镜治疗对子宫内膜息肉所致异常子宫出血患者疗效、EP复发率的影响。方法:试验对象选择为我院2019.10—2020.10收治的80例子宫内膜息肉所致异常子宫出血患者,按照随机数字表法将其分为研究组(40例)与对照组(40例),分别采取宫腔镜电切术和传统刮宫术治疗,就两种术式的应用效果进行对比。结果:研究组患者治疗总有效率(95.00%)相比于对照组(75.00%)更高,EP复发率(5.00%)相比于对照组(30.00%)更低,手术时间、住院时间相比于对照组更短,术中出血量相比于对照组更少,术后并发症发生率(5.00%)相比于对照组(27.50%)更低,统计学分析显示P<0.05。结论:对子宫内膜息肉所致异常子宫出血患者应用宫腔镜电切术进行治疗可取得很好的临床疗效,且手术操作简单、创伤性小、术后恢复快、并发症少。