简介:AbstractPreoperative neoadjuvant chemoradiotherapy, combined with total mesorectal excision, has become the standard treatment for advanced localized rectal cancer (RC). However, the biological complexity and heterogeneity of tumors may contribute to cancer recurrence and metastasis in patients with radiotherapy-resistant RC. The identification of factors leading to radioresistance and markers of radiosensitivity is critical to identify responsive patients and improve radiotherapy outcomes. MicroRNAs (miRNAs) are small, endogenous, and noncoding RNAs that affect various cellular and molecular targets. miRNAs have been shown to play important roles in multiple biological processes associated with RC. In this review, we summarized the signaling pathways of miRNAs, including apoptosis, autophagy, the cell cycle, DNA damage repair, proliferation, and metastasis during radiotherapy in patients with RC. Also, we evaluated the potential role of miRNAs as radiotherapeutic biomarkers for RC.
简介:Thecombinationofradiotherapy(RT)andfunction-preservingsurgeryisthemostusualcontemporaryapproachinthemanagementofsofttissuesarcomas(STS).Pre-andpostoperativeRTresultinsimilarlocalcontrolrates,asshownbyalandmarktrialinextremitySTS.Inthisreview,theroleofRTinthemanagementofextremitySTSwillbediscussed,butSTSinothersites,includingretroperitonealSTS,willalsobeaddressed.ThefocuswillconsidervariousaspectsofRTincludingstrategiestoreducethevolumeoftissuebeingirradiated,dose,scheduling,andthepossibleofomissionofRTinselectedcases.Finally,technologyadvancesthroughtheuseofintensity-modulatedradiotherapy(IMRT),image-guidedIMRT,intraoperativeradiotherapy(IORT)andparticletherapywillalsobediscussed.
简介:两个队伍,24场战役,一个新传奇的诞生……我不会在乎人们说什么,我在乎的是结果。1983年,托尼·杰克林率领斗志昂扬的欧洲选手,和杰克·尼克劳斯手下彪悍的美国队员,狭路相逢在佛罗里达。虽然欧洲人以微弱的优势输给美国人,但却是他们最接近"莱德杯"的一刻。1985年,夺冠的重任再次落到杰克林的肩上,尽管长期生活在美国人阴影下的欧洲人多少有点儿自卑心理作祟,但杰克林决定要扭转这一切。1985年,杰克林将"莱德杯"再次带回欧洲,1989年那场动人心魄的欧美大战结束后,托尼·杰克林也完成了他光荣的命,即使身后的光环渐渐褪去,他永远是"莱德杯"历史上最成功的队长。
简介:Incomparisonwiththenormalpeoplegroup,valuesofbloodCD2+andCD4+inpa-tientswithmallgnanttumorstreatedwithradiotherapyandchemotherapyweresignificantlylowerandtheratioofCD助+andCD8+decreasedobviously(allP<0.001);CD8+hadnoapparentchange(P>0.05).Followingacupuncturaltreatment,valuesofCD2+,CD4+andtheratioofCD4+toCD8+increasedobviously(allP<0.001);whilethoseofthemedicinalcontrolgrouphadnosignificantchangeaftertreatment(P>0.05).ValuesofIgG,IgAandIgMinpatients’serumpresentedanabnormalde-creasingorincreasingtendency,andC3inminorityofpatientswereraised.ResultsindicatedthattherewasabiphasicregulatoryeffectofacupunctureonthedisturbanceofhumoralimmunityandcouldcorrectthedeviationofC3level;anditseffectwasbetterthanorsimilartothatofthemedicinecontrolgroup.Itdemonstratesthatacupuncturecanenhanceandregulate.theimmunefunctionofpa-tientstreatedwithradiotherapya