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简介：Inthepresentpaper,theauthorsreportafewoftypicalcasesofalergicdiseasesincludingpotlinosis,asthma,redeyesandswellingfaceanddermatitistreatedwithotopointsandsomebackshu-pointsaccordingtothesymptoms.Theresultshowedthatthecurativeeffectwassatisfactory.Itindicatesthatotopointshaveagoodantlanaphylacticeffect.

简介：针刺印堂、迎香、肺俞、风池、上星和合谷等穴位，配合推拿头部，面部和躯干部，治疗变应性鼻炎患者38例。结果痊愈16例，显效18例，无效4例。

简介：AbstractBackground:Allergic rhinitis (AR) is characterized by mucosal inflammation that leads to a variety of symptoms, such as nasal congestion, rhinorrhea, and sneezing. This rhinitis is triggered by inhalation of allergens, such as pollen, and this condition has a negative impact on the quality of life. AR was shown to be associated with a number of co-morbidities, including hypothyroidism, asthma, and chronic sinusitis.Objective:This study aimed to assess AR-associated comorbidities in patients presenting symptoms and paranasal sinus computed tomography (CT) scan findings in Taif City, Saudi Arabia.Methods:This cross-sectional study evaluated medical and radiological records of AR patients retrospectively from the period of December 2018 to September 2019 in Al-Hada Armed Forces Military Hospital, Taif City, Saudi Arabia.Results:A total of 103 AR patients with a mean age of 39.0 ± 15.6 years with 55.3% males and 44.7% females. The three most common associated comorbidities in allergic rhinitis patients were chronic sinusitis (28.2%), hypothyroidism (21.4%), and asthma (8.7%). Nasal obstruction (30.1%) was the symptom most frequently presented by all patients. Mucosal thickening occurred most frequently in patients with associated chronic sinusitis, while bilateral osteomeatal complex obliteration was observed mostly in asthmatic patients, and bony boundary thinning was more prevalent among patients with associated hypothyroidism.Conclusion:The gender distribution of AR was 10% more common among males; however, the most common three comorbidites in allergic rhinitis patients were chronic sinusitis, hypothyroidism, and asthma, and most of those patients were females. Hypothyroidism can be a hidden predisposing factor for AR, while chronic sinusitis can be caused by AR due to secretion stasis or immune system activation.

简介：AbstractRising emissions of greenhouse gases in the atmosphere have warmed the planet substantially and are also accompanied by poor air quality. The increased prevalence of allergic airway disease worldwide can be partially attributed to those global environmental changes. Climate change and air pollution pose adverse impacts on respiratory allergies, and that the mechanisms are complex and interactive. Adverse weather conditions, such as extreme temperatures, can act directly on the respiratory tract to induce allergic respiratory illnesses. Thunderstorms and floods can alter the production and distribution of aeroallergens while wildfires and dust storms increase air pollution, and therefore indirectly enhance health risks. Concentrations of particulate matter and ozone in the air have been projected to increase with climate warming and air stagnation, and the rising temperatures and CO2 increase pollen, molds, and spores, which escalate the risk of allergic respiratory diseases. The synergistic effects of extreme heat and aeroallergens intensify the toxic effect of air pollutants, which in turn augment the allergenicity of aeroallergens. With the Earth’s climate change, migration of humans and plants shift the living environments and allergens of susceptible people. Urban residents are exposed to multiple factors while children are sensitive to environmental exposure. Since climate change may pose many unexpected and persistent effects on allergic respiratory diseases, health professionals should advocate for effective mitigation and adaptation strategies to minimize its respiratory health effects.

简介：PurposeThisstudywasdonetoverifytheeffectivenessofacupuncturetreatmentonnasalobstructioncausedbyallergicrhinitisorrhinosinusitis,andtoknowtheclinicaleffectofanovelacupuncturepointnamedSim-eui.MethodRhinitispatientswithatleasttwovisitstothehospitalfromSeptember,2009toNovember,2009wererandomizedintoeitherexperimentorcontrolgroup.Theexperimentgroupweretreatedwithacupunctureongenerallyusedpointsofrhinitis,thatareGV22,GV23,GV24,ST8(bothsides),BL2(bothsides),ST4(bothsides),aswellasSim-euipoint.ThecontrolgroupweretreatedwiththegeneralpointsandLI20(bothsides)insteadofSim-euipoint.Acupunctureneedleswereleftinfor15minutesforbothgroups.TheinitialandfinalsymptomscoresofSNOT-20andamodifiedVASwereusedtoevaluatetheeffectiveness.TheprogramusedforstatisticalanalysiswasSPSS15.0forwindow.WilcoxonSignedRanksTestwasdonetoanalyzetheintra-groupsymptomscorechangebeforeandaftertreatment,andMann-WhitneyTestwasusedtocompareinter-groupVASchange.Allthestatisticswereverifiedatasignificancelevelof5%.ResultTheSNOT-20scoresbeforeandafteracupuncturetreatmentshowedsignificantchangesonbothexperimentandcontrolgroups,buttherewasnosignificantdifferencebetweenthetwogroups.AllcategoriesoftheSNOT-20showedsignificantresult,exceptthe'Wakeupatnight'and'Lackofagoodnight'ssleep'entries.ThemodifiedVASshowedsignificantimprovementofsymptomintheexperimentgroupcomparedwithcontrolgroup.ConclusionAcupuncturetreatmentusingSim-euipointseemstobehelpfulinimprovingqualityoflifebyimmediatereliefofnasalobstruction.

简介：有编码Dermatophagoidespteronyssinus组2的DNA的种痘(Derp2)变应原以前在Derp上显示出它immunologic保护的效果在老鼠的2导致变应原的过敏航线发炎。在现在的学习，我们调查了是否2能施加的DNA疫苗编码Derp在老鼠模型的导致变应原的过敏航线发炎上的治疗学的角色并且在气喘探索了DNA种痘的机制特定变应原的免疫疗法。在由Derp敏化并且质问以后2，BALB/c老鼠与DNA被使免疫疫苗。细胞的渗入的度被获得。在浆液的IgE层次和在BALF的IL-4/lL-13层次被ELISA决定。肺纸巾被组织学的考试估计。在肺的STAT6和NF-B的表情被染色的immunohistochemistry决定。有DNA疫苗的老鼠的种痘禁止了航线发炎和变应原导致的粘蛋白的生产的发展，并且减少了Derp2-specificIgE水平的水平。eosinophii渗入的重要减小和在BALF的IL-4andIL-13的层次在种痘以后被观察。进一步更，DNA种痘在Derp2-immunized老鼠在肺织物禁止了STAT6和NF-Bexpression。这些结果显示DNA疫苗编码Derp2allergen能在我们的老鼠模型被用于导致变应原的过敏航线发炎的治疗。

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简介：到真菌的促进感受性经常导致是特别地困难的临床上设法的气喘的一种严重形式，导致在这些病人的增加的病态和住院。尽管B淋巴细胞可能通过IgE的生产加重气喘症状，这些房间可能也在对吸入的真菌的保护的反应是重要的。通过cytokine版本和T房间相互作用，这些淋巴细胞可能也影响航线墙纤维变性的发展和维护。JH−/−老鼠为抗体的重链部件缺乏JH基因，它为B房间功能和幸存是批评的。这些动物在很多有免疫力的回答便于B淋巴细胞的角色的说明；然而，JH−/−老鼠没被用来学习真菌的过敏症。在这研究，我们用曲霉属菌fumigatus检验了B淋巴细胞的角色模仿被环境真菌的暴露触发的人的航线疾病的鼠科的真菌的高空过敏症模型。我们在敏化的野类型的BALB/c和J暴露于的H−/−老鼠重复了真菌的暴露并且没在大航线附近在航线hyperresponsiveness，全面肺的发炎或骨胶原免职发现差别。然而，Th2类型cytokinesIL-4和IL-13的层次显著地在J相对BALB/c控制的H−/−鼠标。由对比，煽动性的cytokinesIL-17A和IL-6的层次显著地在JH−/−动物，并且有显著地更柔韧的航线嗜曙红血球过多和neutrophilia比在控制动物。一起拿，这些调查结果表明淋巴细胞帮助在肺的分隔空间调整granulocytic回答到真菌的暴露的那B。

简介：BACKGROUND:Olfactoryensheathingcelltransplantationcanactivateaxonalregenerationandenhancemyelinrepair,whicharebeneficialfortreatingdemyelinatingdiseases.OBJECTIVE:Toexploretheeffectsofolfactoryensheathingcelltransplantationonmyelinrepair,synaptophysinexpression,andmotorfunctioninaratmodelofexperimentalallergicencephalomyelitis.DESIGN,TIMEANDSETTING:Arandomized,controlledexperimentwasperformedattheLaboratoryofProvincialHospitalaffiliatedtoShandongUniversitybetweenAugust2006andSeptember2007.MATERIALS:Dibenzylamine(Hoechst33342),luxolfastblue,andrabbitanti-ratsynaptophysinantibodywereprovidedbySigma,USA.METHODS:OlfactoryensheathingcellsextractedfromneonatalWistarratswereculturedfor10-14daysandlabeledwithdibenzylamine.SpinalcordextractedfromahealthyguineapigwashomogenizedandequallymixedwithcompleteFreund'sadjuvant;thereafter,themixturewasintracutaneouslyinjectedintotwoposteriorvoixpedisofhealthymaleWistarratstoestablishmodelsofexperimentalallergicencephalomyelitis.Ratswererandomlydividedintoacontrolencephalomyelitisgroupandanolfactoryensheathingcelltransplantationgroup,36ratsineachgroup.Physiologicalsaline(2μL)oranolfactoryensheathingcellsuspension(2μL)wasseparatelyinjectedalonglateralcerebralventricleatday7post-modelinduction.MAINOUTCOMEMEASURES:Themigrationanddistributionofolfactoryensheathingcellswereobservedunderfluorescencemicroscopy;myelinrepairwasdetectedusinghematoxylin-eosinstainingandluxolfastbluestaining;synaptophysinexpressionwasmeasuredusingimmunohistochemicalstaining;motorfunctionwasevaluatedusingamotorfunctionscale.RESULTS:Olfactoryensheathingcellscouldsurviveinvivoandmigratetothedistalendofthetransplantfocusandspinalcord,andsurvived21days.Hematoxylin-eosinstainingandluxolfastbluestainingindicatedthatmyelininthetransplantationgroupwasintact,andtheinfla

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简介：临床的试用和动物实验的增加的数字显示出细菌为过敏症预防正在答应工具的那probiotic。这里，我们在过敏促进感受性上分析了三选择乳杆菌紧张的immunomodulatory性质和他们的混合的影响赌1用一只gnotobiotic老鼠建模的v。我们显示出那乳杆菌(L.)rhamnosusLOCK0900，L。rhamnosusLOCK0908和L。caseiLOCK0919经由像使用费的受体被认出2(TLR2)并且核苷酸绑定oligomerization包含域的蛋白质2(NOD2)受体并且刺激骨头在种类依赖者和紧张依赖者礼貌生产cytokines的导出髓的树枝状的房间。殖民无菌(GF)有所有三紧张(Lmix)的混合物的鼠标由加强enterocytes的顶端的junctional建筑群并且恢复延续到终端网的微细丝的结构改进了肠的障碍。与Lmix开拓殖民地于并且敏化1变应原到赌注v的老鼠显著地象一个增加的转变生长因素(TGF)一样在sera和肠的lavages显示出变应原特定的IgE，IgG1和IgG2a和提高的全部的IgA水平的底层-β；与敏化的GF老鼠相比铺平。从开拓殖民地于Lmix的老鼠的Splenocytes和mesenteric淋巴节点房间显示出TGF-β的重要upregulation；在以后在有赌注v的vitro刺激1。我们的结果证明Lmix殖民改进了内脏对赌注v的上皮的障碍和减少的过敏促进感受性1。而且，这些调查结果被传播和能分泌的IgA和规章的cytokineTGF-β的增加的生产伴随；。因此，三乳杆菌紧张的这混合物在人在增加的内脏渗透和过敏症的发作的预防为使用显示出潜力。

简介：我们证明了装载Hsp60sp的不成熟的树枝状的房间(DC/sp)能由导致Qa-1-restrictedCD8+T保护老鼠免受试验性的过敏脑脊髓炎(EAE)的正式就职的伤害规章(Treg)房间。在Qa-1和Hsp60sp之间的有约束力的半衰期是特别地短的并且导致显著地减少的不稳定的Qa-1/peptide建筑群这种痘的功效。阻止Qa-1/Hsp60sp复杂分离，我们利用了paraformaldehyde(PFA)稳定Qa-1/Hsp60sp建筑群的形成并且作为一支疫苗最大化DC/sp的函数控制自体免疫的疾病的固定。与非修理的DC/sp相比，固定DC/sp(FDC/sp)显示了一个提高的能力激活Qa-1-restrictedHsp60sp特定的CD8+在vitro的T房间和在vivo的阻止的EAE。重要地，FDC/sp在4°为72h维持了有免疫力的活动追随者cryopreservation1个星期或在存储以后；C。这些结果显示那PFA固定能由在DC/sp的表面上改进Qa-1/Hsp60sp建筑群的稳定性支撑或增加DC/sp的功效。另外，PFA固定为DC/sp存储，运输和申请创造一扇时间窗户。我们的数据为自体免疫的疾病的预防和治疗作为一支疫苗建议FDC/sp的潜在的临床的使用。

简介：AbstractBackground:It is still unclear if and to what extent antenatal or infant or childhood vitamin D supplementation would affect the development of allergy diseases later in life. This study aimed to review the efficacy of vitamin D supplementation in pregnant women, infants, or children for the prevention of allergies.Methods:MEDLINE (PubMed), EMBASE (OVID), and the Cochrane Central Register of Controlled Trials were searched up to March 1, 2020. We included only randomized controlled trials (RCTs). We performed a systematic review and meta-analysis for vitamin D supplementation in primary allergy prevention. These trials were assessed for risk of bias using the Cochrane Collaboration domains and the consensus was reached via discussion with the full study group. We descriptively summarized and quantitatively synthesized original data to evaluate vitamin D supplementation in primary allergy prevention by using Review Manager software for meta-analysis.Results:The search yielded 1251 studies. Seven RCTs were included in this analysis. A meta-analysis revealed that vitamin D supplementation for pregnant women or infants may not decrease the risk of developing allergic diseases, such as asthma or wheezing (supplementation for pregnant women, risk ratio [RR]: 1.01, 95% confidence interval [CI]: 0.81-1.26, P = 0.90, I2 = 47%; supplementation for infants, RR: 1.00, 95% CI: 0.70-1.43, P = 0.99, I2 = 0%; supplementation for pregnant women and infants, RR: 0.35, 95% CI: 0.10-1.25, P= 0.11), eczema (supplementation for pregnant women, RR: 0.95, 95% CI: 0.80-1.13, P= 0.77, I2= 0%; supplementation for infants, RR: 0.84, 95% CI: 0.64-1.11, P= 0.19, I2= 42%), allergic rhinitis (supplementation for pregnant women, RR: 0.93, 95% CI: 0.78-1.11, P = 0.15, I2 = 47%), lower respiratory tract infection (LRTI) (supplementation for pregnant women, RR: 0.97, 95% CI: 0.85-1.11, P = 0.59, I2 = 0%), or food allergy.Conclusions:Supplementation of vitamin D in pregnant women or infants does not have an effect on the primary prevention of allergic diseases.Systematic Review Registration:PROSPERO (CRD42020167747)

简介：【摘要】目的：分析穴位贴敷疗法配合针灸治疗过敏性鼻炎(Allergic rhinitis,AR)的临床疗效。方法：选择我诊所2021年1月-2022年1月过敏性鼻炎患者共70例，数字表随机分2组每组35例，对照组的患者给予糠酸莫米松鼻喷雾剂治疗，观察组在该基础上增加穴位贴敷疗法配合针灸治疗。比较两组治疗前后患者鼻痒、鼻塞、流涕、喷嚏症状积分、总有效率、不良反应。结果：观察组治疗后患者鼻痒、鼻塞、流涕、喷嚏症状积分低于对照组，总有效率高于对照组，P＜0.05。两组治疗过程不良反应未见，P＞0.05。结论：穴位贴敷疗法配合针灸治疗对于过敏性鼻炎的治疗效果确切，可有效缓解患者临床症状，且安全性高。