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简介：AbstractInfertility seriously endangers the reproductive health of women at childbearing age. It is defined as the failure to achieve successful pregnancy after 1 year or more of regular unprotected intercourse. Broadly defined, infertility includes two aspects - failure to conceive or have a live birth. This guideline only addressed content relevant to the former. It was proposed by the gynecological endocrine group of the Chinese Society of Obstetrics and Gynecology, Chinese Medical Association, based on relevant guidelines of the World Health Organization, the American Society for Reproductive Medicine, the National Institute for Health and Clinical Excellence, as well as the clinical practice in China. The guideline was reviewed by experts and doctors from medical institutions at all levels, which is applicable to the diagnosis of infertility by physicians in obstetrics, gynecology, and andrology at various medical institutions nationwide.

简介：ＢｅａｍＤｉａｇｎｏｓｔｉｃＳｙｓｔｅｍｆｏｒＳＦＣ￥ＳｏｎｇＨａｉｈｏｎｇＴｈｅｄｉａｇｎｏｓｔｉｃｄｅｖｉｃｅｓｆｏｒｔｈｅｉｎｊｅｃｔｏｒＳＦＣｉｎｃｌｕｄｅ３ｍｏｖａｂｌｅｒａｄｉａｌｐｒｏｂｅｓｗｉｔｈ１０ｄｉｆｆｅｒｅｎｔｉａｌａｎｄｉｎ...

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简介：StabilizedorChebyshevexplicitmethodshavebeenwidelyusedinthepasttosolvestiffordinarydifferentialequations.MakinguseofspecialpropertiesofChebyshev-likepolynomials,thesemethodshavefavorablestabilitypropertiescomparedtostandardexplicitmethodswhileremainingexplicit.Anewclassofsuchmethods,calledROCK,introducedin[Numer.Math.,90,1-18,2001]hasrecentlybeenextendedtostiffstochasticdifferentialequationsunderthenameS-ROCK[C.R.Acad.Sci.Paris,345(10),2007andCommun.Math.Sci,6(4),2008].InthispaperwediscusstheextensionoftheS-ROCKmethodstosystemswithdiscretenoiseandproposeanewclassofmethodsforsuchproblems,theT-ROCKmethods.Onemotivationforsuchmethodsisthesimulationofmulti-scaleorstiffchemicalkineticsystemsandsuchsystemsarethefocusofthispaper,butournewmethodscouldpotentiallybeinterestingforotherstiffsystemswithdiscretenoise.TwoversionsoftheT-ROCKmethodsarediscussedandtheirstabilitybehaviorisanalyzedonatestproblem.ComparedtotheT-leapingmethod,asignificantspeed-upcanbeachievedforsomestiffkineticsystems.Thebehavioroftheproposedmethodsaretestedonseveralnumericalexperiments.

简介：HL-2Atokamakisthefirstnon-circularcross-sectiontokamakwithdivertorinChina.ApartfromboundarytransportandSOLstudy,theHL-2AmajorsubjectistoinvestigatetheimprovementofconfinementwithhighparametersandalotoffrontphysicsandrelevantengineeringtechniquesbyuseofitsspecialCloseddivertorwithlargevolumeinChina.

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简介：Inthispaper,standardandeconomicalcascadicmultigridmethodsareconsideredforsolvingthealgebraicsystemsresultingfromthemortarfiniteelementmethods.Bothcascadicmultigridmethodsdonotneedfullellipticregularity,sotheycanbeusedtotacklemoregeneralellipticproblems.Numericalexperimentsarereportedtosupportourtheory.

简介：AbstractAlthough whole-exome sequencing and whole-genome sequencing has tremendously improved our understanding of the genetic etiology of human disorders, about half of the patients still do not receive a molecular diagnosis. The high fraction of variants with uncertain significance and the challenges of interpretation of noncoding variants have urged scientists to implement RNA sequencing (RNA-seq) in the diagnostic approach as a high throughput assay to complement genomic data with functional evidence. RNA-seq data can be used to identify aberrantly spliced genes, detect allele-specific expression, and identify gene expression outliers. Amongst eight studies utilizing RNA-seq, a mean diagnostic uplift of 15% has been reported. Here, we provide an overview of how RNA-seq has been implemented to aid in identifying the causal variants of Mendelian disorders.

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简介：付春敏老师向我们推荐了这篇罗德尼·马丁有关教师在培养学生写作结构中促进思维能力发展的文章。在文中我们可以看到,以英文为母语的西方,教师更加着力于对学生的构思结构"大局"观的思维培养。文中对培养学生写作结构思维能力的剖析,望能对老师们的教育教学有所启示。

简介：BioscienceMethods(ISSN1925-1920)isanopenaccess,peerreviewedjournalpublishedonlinebyBioPublisher.Thejournalpublishesallthelatestandoutstandingresearcharticles,lettersandreviewsinallareasofbioscience,therangeoftopicsincluding(butarenotlimitedto)technologyreview,techniqueknow-how,labtool,statisticalsoftwareandknown

简介：BioscienceMethods(ISSN1925-1920)isanopenaccess,peerreviewedjournalpublishedonlinebyBioPublisher.Thejournalpublishesallthelatestandoutstandingresearcharticles,lettersandreviewsinallareasofbioscience,therangeoftopicsincluding(butarenotlimitedto)technologyreview,techniqueknow-how,labtool,statisticalsoftwareandknown

简介：BioscienceMethods(ISSN1925-1920)isanopenaccess,peerreviewedjournalpublishedonlinebyBioPublisher.Thejournalpublishesallthelatestandoutstandingresearcharticles,lettersandreviewsinallareasofbioscience,therangeoftopicsincluding(butarenotlimitedto)technologyreview,techniqueknow-how,labtool,statisticalsoftwareandknowntechnologymodification.Casestudiesontechnologiesforgenediscoveryandfunction

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简介：为非线性的系统的诊断计划基于neurofuzzy联网的一个联机差错在这篇论文被建议。计划包含二个阶段。在第一个阶段，非线性的系统被一个neurofuzzy网络接近，它从在系统的正常操作期间获得的数据脱机被训练。在第二个阶段，剩余从这个网络在网上被产生并且被在网上训练的另一个neurofuzzy网络建模。模糊规则从这个网络被提取，并且与在在不同有缺点的操作，差错从被诊断下面获得的差错数据库的那些相比。建议聪明的差错计划的性能在不同有缺点的条件下面用一个二坦克的水水平控制系统被说明。