简介：

简介：Toobservetheeffectsofdifferentacupuncturemanipulationsonbloodpressureandtargetorgandamageinspontaneouslyhypertensiverats(SHRs),thisstudyusedthereinforcingtwirlingmethod(1.5–2-mmdepth;rotatingneedleclockwisefor360°andthencounterclockwisefor360°,withthethumbmovingheavilyforwardandgentlybackward,60timesperminutefor1minute,andretainingneedlefor9minutes),thereducingtwirlingmethod(1.5–2-mmdepth;rotatingneedlecounterclockwisefor360°andthenclockwisefor360°,withthethumbmovingheavilybackwardandgentlyforward,60timesperminutefor1minute,andretainingneedlefor9minutes),andtheneedleretainingmethod(1.5–2-mmdepthandretainingtheneedlefor10minutes).BilateralTaichong(LR3)wastreatedbyacupunctureusingdifferentmanipulationsandmanualstimulation.Reinforcingtwirling,reducingtwirling,andneedleretainingresultedinadecreasednumberofapoptoticcells,reducedBaxmRNAandproteinexpression,andanincreasedBcl-2/BaxratiointhehippocampuscomparedwiththeSHRgroup.Amongthesegroups,theBcl-2/Baxproteinratiowashighestinthereducingtwirlinggroup,andtheBcl-2/BaxmRNAratiowashighestintheneedleretaininggroup.Theseresultssuggestthatreinforcingtwirling,reducingtwirling,andneedleretainingmethodsallimprovebloodpressureandpreventtargetorgandamagebyincreasingthehippocampalBcl-2/BaxratioandinhibitingcellapoptosisinthehippocampusinSHR.

简介：它被看那，在一种开的梯子类型有自发地产生的连贯(SGC)的原子系统不管支离破碎的抽的存在，一没有获得总是是的倒置(LWI)，放射激光显著比在没有SGC的系统大，由调整SGC的力量。而且，在没有支离破碎的抽的系统的LWI获得与支离破碎的抽比那大得多，在SGC的一些力量以内；当时在有SGC的相应封闭系统，我们不能在SGC的任何力量获得LWI获得，如果没有支离破碎的抽被使用。CLC数字O43.1+2文件代码A

简介：Weinvestigatetheeffectsofspontaneouslygeneratedcoherence(SGC)onboththesteadyandtransientgainpropertiesinafour-levelinverted-Y-typeatomicsysteminthepresenceofaweakprobe,twostrongcoherentfields,andanincoherentpump.Forthesteadyprocess,wefindthattheinversionlessgainmainlyoriginsfromSGC.Inparticular,wecanmodulatetheinversionlessgainbychangingtherelativephasebetweenthetwofields.Moreover,theamplitudeofthegainpeakcanbeenhancedandtheadditionalgainpeakcanappearbychangingthedetuningofthecouplingfield.Asforthetransientprocess,thetransientgainpropertiescanalsobedramaticallyaffectedbytheSGC.ComparedtothecasewithoutSGC,thetransientgaincanbegreatlyenhancedwithcompletelyeliminatedtransientabsorptionbychoosingtheproperrelativephasebetweenthetwofields.Andtheinverted-Y-typesystemwithSGCcanbesimulatedinbothatomicandsemiconductorquantumwellsystemsavoidingtheconditionsofSGC.

简介：Background:Ketamineisappliedwidelyforsedationduringcardiaccatheterizationinspontaneouslybreathingchildrenwithcongenitalheartdisease(CHD).However,arareandunreportedrespiratorycomplication,transientandreversibleatelectasisoflungs(TRAL),wasidentified.Purpose:ThestudywasperformedtoinvestigateretrospectivelytheprevalenceandclinicalcharacteristicsofTRALafterketaminesedationinpediatriccardiaccatheterization.Methods:Fourthousandfourhundredandseventy-foursickchildrenweresedatedwithketamine,andpediatriccardiaccatheterizationwascarriedoutunderspontaneousbreathing.TRALwasdetectedin33children(17M/16F,agewas2.1±1.7years)byretrospectiveanalysis.Theclinicalandradiographiccharacteristicswererecordedbefore,duringandafterTRAL.Results:Inpediatriccardiaccatheterization,theprevalenceofTRALwas0.74%afterketaminesedation.TRALoccurredin23childrenwithcyanoticCHD,and10withacyanoticCHD.AllTRALshadcommonclinicalandradiographicfeatures:thediffuseopacityofbilaterallungsdevelopedrapidly(identifiedunderX-rayfluoroscopy),associatedwithdecreaseinlungvolume,andthenthedecreaseinSpO2(94.2±9.2%vs.59.4±2.2%,P<0.05),andheartrates(143.5±14.3bpmvs.58.3±9.7bpm,P<0.05)followedquickly.TRALwasrelievedbysupportiveoxygenin32children(23withfacemask,and9withendotrachealintubation),andthedurationofTRALwas1.6±0.5minutes.However,TRALcausedthedeathofonechild.Conclusions:TRALisarareandurgentrespiratorycomplicationafterketaminesedation,andthemechanismisunclear.RapidanddiffuseopacityofbilaterallungsistheearliestsignofTRALinpediatriccardiaccatheterization,andtheimmediatesupportiveoxygeniscrucial.

简介：高血压生产为与疾病联系的死亡经常负责的pathophysiological变化。overactive高血压蛋白原酶血管收缩素系统在高血压和与高血压联系的目标机关损坏的发展起一个中央作用，是明显的。我们以前发现了新奇血管收缩素受体(AT1)vaccine-ATR12181在自发地高血压的老鼠(SHR)稀释了高血压(BP)的发展人的必要高血压的模型。我们的目的是决定高BP的这变细是否与由高血压的状态导致的目标机关损坏的预防被联系。SHR被在联合复杂的peptide-tetanus-toxoid的重复下的注射与Freund的助手从AT1A受体的extracelluar部分对肽(编码ATR12181)使免疫。64个星期长期的观察被执行。重复种痘导致了anti-ATR12181抗体的正式就职。在观察的结束，种牛痘表明的SHR降低肾损害的BP，减少的心脏的肥大和变细。在心和肾的c-fos和c-jun的mRNA层次在种牛痘的SHR被减少。因为自我抗原被使用，疫苗的安全被担心。然而，自体免疫的疾病的符号没在心和肾的节被观察。这些数据证明对AT1受体的细胞外的部分的域的那重复免疫能对高血压引起一个目标机关保护。对AT1受体的活跃免疫可以在高血压的治疗被看作有希望的新策略。

简介：Toinvestigatethetreatmenteffectof2-seleniumbridgedβ-cyclodextrin(2-SeCD),aGPXmimic,onthestrokeofstroke-pronespontaneouslyhypertensiverats(SHRSP),fifty-twoSHRSPof8-weekoldwererandomlydividedintofourgroupsA,B,CandcontrolgroupD.TheratsofgroupsA,B,CandDweregiven1.0%-1.5%NaClmassfractionasdrinkingfluid.Afteronsetofstroke,groupsA,BandCweregivenorally16.05,160.5and1605mg*kg-1*day-1of2-SeCD,respectively,andgroupDwasgivenwaterfor2weeks.Theclinicalscoreofstroke,systolicbloodpressure(SBP),survivaltimeofratswererecordedandthehistopathologicexaminationsoftheirbrainandcarotidarteryweremadeafterdecapitation.Theclinicalscoresofstrokeaftertreatmentwith160.5mg*kg-1*day-1(GroupB)and1605mg*kg-1*day-1(GroupC)of2-SeCDare2.55±0.98and1.98±0.79,respectively,thoseareobviouslylowerthanthatofgroupD(3.41±0.83,p<0.01).ThesurvivaldaysingroupB(10.0±8.6)andgroupC(14.4±7.9)arelongerthanthatforgroupD(4.7±2.9,p<0.01).TheelectronmicroscopestudyshowedthattheendotheliumofcarotidarterywasneartonormalingroupBandgroupC,whileitwasseriouslyinjuredincontrolgroupDandmildlyinjuredingroupA.2-SeCDmayeffectivelybeusedtotreatthestrokeforSHRSP.

简介：无

简介：Basementmembranedegradationandblood-brainbarrierdamageappearaftercerebralinfarction,severelyimpactingneuronalandbrainfunctioning;however,theunderlyingpathogeneticmechanismsremainpoorlyunderstood.Inthisstudy,weinducedcerebralinfarctioninstrokepronespontaneouslyhypertensiveratsbyintragastricadministrationofhigh-sodiumwater(1.3%NaCl)for7consecutiveweeks.Immunohistochemicalandimmunofluorescenceassaysdemonstratedthat,comparedwiththenon-infarctedcontralateralhemisphere,stroke-pronespontaneouslyhypertensiveratsonnormalsodiumintakeandWistar-Kyotorats,matrixmetalloproteinase-9expression,thenumberofbloodvesselswithdiscontinuouscollagenIVexpressionandmicrovesseldensityweresignificantlyhigher,andthenumberofcontinuouscollagenIV-positivebloodvesselswaslowerintheinfarctborderzonesofstroke-pronespontaneouslyhypertensiveratsgivenhigh-sodiumwater.Linearcorrelationanalysisshowedmatrixmetalloproteinase-9expressionwaspositivelycorrelatedwiththenumberofdiscontinuouslycollagenIV-labeledbloodvesselsandmicrovesseldensityincerebralinfarctsofstroke-pronespontaneouslyhypertensiverats.Theseresultssuggestthatmatrixmetalloproteinase-9upregulationisassociatedwithincreasedregionalangiogenesisanddegradationofcollagenIV,themajorcomponentofthebasallamina,instroke-pronespontaneouslyhypertensiveratswithhigh-sodiumwater-inducedfocalcerebralinfarction.