简介:AIMToobservethetherapeuticeffectofmoxibustiononulcerativecolitisanditsinfluenceonthecolonicmucosalmorphology.METHODSForty-sixpatientswithulcerativecolitiswererandomlydividedintothemoxibustionwithherbalmedicineunderneathgroupandthewesternmedicinegroup.Thirtypatientsweretreatedwiththeabovemoxibustionand16patientswithSalicylayefapyridine(SASP).Thecolonicmucosaof13patientsinthemoxibustiongroupwasobservedbycolonoscopybeforeandafterthetreatment.MucinwasalsoanalyzedbyH.EandAB-PASstaining.RESULTSSeventeenpatientswereclinicallycured,12wereimprovedand1unchangedinthemoxibustiongroup.Inthecontrolgroup,5patientswereclinicallycured,7improvedand4unchanged.ThirteenpatientswithactiveUCweretakenasthesubjectsforhistopathologicanalysisinthisstudy.Thecolonicmucosallesionswereremarkablyimprovedandthecharacteristicofthemucinalsochanged.Inmostsections,thechronicinflammationofmucosawasgeatlyameliorated(P<0.01).Theinflammatorycellinfiltratationmuchdecreasedandneutrophils,disapearedinmostsections(P<0.001).Thegobletcellssignificantlyincreased(P<0.001);cryptparacryptabscessormucosalulcerationwasseen(P<0.001).CONCLUSIONTherateofcureofulcerativecolitisbymoxibustionwithherbalmedicinebeneathissuperiortothatbySASP.Thissortofmoxibustioncaneffectivelyimprovethecolonicmucosallesionsandrestoretheproportionofmucoproteintonearnormal.