简介：vivoXshot的后置镜头采用了1300万像素的S0NY第二代堆栈式传感器和F1．8超大光圈6P镜头，信噪比的提升和光圈增大，让手机在弱光、暗光环境下的拍照能力越好。

简介：<正>近日,vivoXshot手机在北京全球首发,旗舰版内置骁龙8018974AC处理器,精英版为骁龙8018974AA处理器,配备5.2英寸显示器,拥有1300万/800万像素摄像头,支持4K视频录制,其中旗舰版支持5模13频,在全球范围内支持LTETDD/LTEFDD/TDSCDMA/WCDMA/GSM。Qualeomm全球副总裁沈劲表示,骁龙801处理器中每个关键处理引擎性能都极为卓越,包括CPU,GPU,DSP,摄像头传感器和内存组件等。通过更大并且更快的摄像头传感器和更强的影像后处理,为vivoXshot带来更高质的图像。此外,骁龙801内置双影像信号处理器(ISP),使得Xshot可以更快速地采集和编辑更清晰的影像,并处理数量庞大的视觉数据输入。

简介：客观：为了调查与外部fixator在处理期间测量主要axials火车的不同方法并且发现，合适的压缩在一个早阶段由外部fixator装载了。方法：十八只健康大耳朵的兔子随机根据不同测量方法被划分成二个组：组织A和组B。在组A，一个紧张计量器与502胶水在外部胫骨的外皮被加，并且在组B，一个骨头cement-coatedstrain计量器在内部胫骨的外皮上被安装。组A和B被划分成二亚群A1，A2和B1，B2，分别地根据一半并且与身体重量一样的压力。Z塑造左中间柄的胫骨的截骨术被externalfixator执行并且修理。结果：组A的sealer曲线在早阶段期间戏剧性地变化了。当后者紧张价值比前者高时，内部、外部的外皮的Thetrendlines在到达稳定的阶段以后一致地去了。到达最稳定的年龄的组B的时间是短的，但是它的绝对紧张价值是不到组A的。在他们被贴在稳定的阶段以前，当亚群B1和B2的结果是一样的时，亚群A1的拒绝的速度比SubgroupA2的慢慢地是更多。在它衰退了以后，当时，组A有一个上升趋势组Bdidn“t。在他们到达了稳定的阶段，两亚群A1和A2had以后一个衰退趋势当亚群A2比亚群A1快速是更多时，当亚群B2波动时，亚群B1在明确的水平被保留。结论：在外部fixatorcan下面的轴的紧张被骨头水泥测量在vivo的涂紧张的计量器。数据可以建议身体重量负担的那一半对外部fixator合适。

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简介：Reliablecomputationalfootmodelsofferanalternativemeanstoenhanceknowledgeonthebiomechanicsofhumanfoot.Modelvalidationisoneofthemostcriticalaspectsoftheentirefootmodelingandanalysisprocess.Thispaperpresentsaninvivoexperimentcombiningmotioncapturesystemandplantarpressuremeasureplatformtovalidateathree-dimensionalfiniteelementmodelofhumanfoot.TheMagneticResonanceImaging(MRI)slicesforthefootmodelingandtheexperimentaldataforvalidationwerebothcollectedfromthesamevolunteersubject.Thevalidatedcomponentsincludedthecomparisonofstaticmodelpredictionsofplantarforce,plantarpressureandfootsurfacedeformationduringsixloadingconditions,toequivalentmeasureddata.Duringthewholeexperiment,footsurfacedeformation,plantarforceandplantarpressurewererecordedsimultaneouslyduringsixdifferentloadedstandingconditions.ThepredictionsofthecurrentFEmodelwereingoodagreementwiththeseexperimentalresults.

简介：Photoacousticophthalmoscopy(PAOM)isanovelimagingmodality,whichiscapableofnon-invasivelydetectingopticalabsorptionpropertiesintheretina.WevisualizethemicrovasculatureinretinaandchoroidinalbinomouseusingPAOMguidedbyspectral-domainopticalcoherencetomography.Sincealbinomousecharacterizesbylackingmelanininretinalpigmentepithelium(RPE),PAOMilluminationlasercanpenetratethroughtheRPEontochoroid,andconsequentlyprovidesvolumetricvisualizationofchorioretinalvasculaturesasaresultofstronghemoglobinopticalabsorption.Thehigh-qualitychorioretinalmicrovascularimagingacquiredbyPAOMimpliesitsgreatpotentialinunderstandingpathologicalmechanismsanddevelopingtherapeuticstrategiesformajorchorioretinaldiseasesthatcorrelatewithvasculardisorders.

简介：几乎，用非自体同源的房间，织物或机关移植的每试验性的治疗策略在临床的翻译前在小、大的动物模型被测试。因为这些策略在大多数情况中要求免疫力的抑制，抑制免疫力的协议是在移植实验的一个关键元素。然而，没有详细知识，标准抑制免疫力的协议经常在特别试验性的背景以内并且在选择模型种类关于他们的功效被使用。如此的协议的优化对到人的病人的试验性的结果的翻译恰当，因此，保证推进调查。这评论与种类特定的药metabolization和副作用的考虑关于抑制免疫力的药类以及他们的剂量和应用程序政体总结当前的知识。它也总结新奇immunomodulatory策略的当代的知识，例如间充质的干细胞或抗体的使用。因此，这评论被打算用作一个最先进的概要让研究人员精制应用试验性的免疫力的抑制和immunomodulation策略提高现出症状之前的潜的移植研究的预兆的价值。

简介：Duringeccentriccontractions,muscularforceproductioncapacityisenhancedcomparedtoisometriccontractions.Althoughthisiswellacceptedintermsofmusclemechanics,maximalvoluntaryeccentriccontractionsareassociatedwithneuralinhibitionthatpreventsincreasedforceproductionofinvivohumanmuscles.However,becauseitwasshownthatmaximalvoluntaryeccentricforcescanexceedmaximumisometricforcesbyafactorof1.2-1.4,thisreviewfocusesonthequestionofwhethertheabsenteccentricforceenhancement,asobservedinmanystudies,canunambiguouslybeattributedtoaninherentneuralinhibition.First,wedemonstratethatparticipantfamiliarization,preload,andfasciclebehaviorarecrucialfactorsinfluencingmaximalvoluntaryeccentricforceproduction.Second,weshowthatmusclemechanicssuchasmusclelength,lengtheningvelocity,andstretchamplitudeinteractwhenitcomestomaximalvoluntaryeccentricforceproduction.Finally,wediscussthedivergingfindingsonneuralinhibitionduringmaximalvoluntaryeccentriccontractions.Becausetherewasnoinhibitionofthemajormotorpathwaysinthepresenceofenhancedmaximalvoluntaryeccentricforces,furtherresearchisneededtotesttheconceptofneuralinhibitionandtounderstandwhymaximalvoluntaryforceproductionisreducedcomparedtotheforcecapacityofisolatedmusclepreparations.

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简介：Recentadvancesinoptogeneticshaveestablishedapreciselytimedandcell-specificmethodologyforunderstandingthefunctionsofbraincircuitsandthemechanismsunderlyingneuropsychiatricdisor-ders.However,thefabricationofoptrodes,akeyfunctionalelementinoptogenetics,remainsagreatchallenge.Here,wereportreliableandefficientfabricationstrategiesforchronicallyimplantableoptrodearrays.Toimprovetheperformanceofthefabricatedoptrodearrays,surfacesoftherecordingsitesweremodifiedusingoptimizedelectrochemicalprocesses.Wehavealsodemon-stratedthefeasibilityofusingthefabricatedoptrodearraystodetectseizuresinmultiplebrainregionsandinhibitictalpropagationinvivo.Furthermore,theresultsofthehistologystudyimplythattheelectrodepositionofcompositeconductingpolymersnotablyalleviatedtheinflammatoryresponseandimprovedneuronalsurvivalattheimplant/neural-tissueinterface.Insummary,weprovidereliableandefficientstrategiesforthefabricationandmodificationofcustomizedoptrodearraysthatcanfulfilltherequirementsofinvivooptogeneticapplications.

简介：Danshensu[3-(3,4-dihydroxyphenyl)lacticacid,DSS],oneofthesignificantcardioprotectivecomponents,isextractedfromtherootofSalviamiltiorrhiza.Inthepresentstudy,anesterprodrugofDanshensu(DSS),palmitoylDanshensu(PDSS),wassynthesizedwiththeaimtoimproveitsoralbioavailabilityandprolongitshalf-life.TheinvitroexperimentswerecarriedouttoevaluatethephysicochemicalpropertiesandstabilityofPDSS.AlthoughthesolubilityofPDSSinwaterwasonly0.055mg·mL~(-1),itssolubilityinFaSSIFandFeSSIFreached4.68and9.08mg·mL~(-1),respectively.Octanol-waterpartitioncoefficient(logP)wasincreasedfrom-2.48ofDSSto1.90ofPDSS.PDSSwasrelativelystableintheaqueoussolutioninpHrangefrom5.6to7.4.Furthermore,thepharmacokineticsinratswasevaluatedafteroraladministrationofPDSSandDSS.AUCandt1/2ofPDSSwereenhancedupto9.8-foldand2.2-fold,respectively,comparedtothatofDSS.Cmaxwas1.67±0.11μg·mL~(-1)forPDSSand0.81±0.06μg·mL-1forDSS.Thus,theseresultsdemonstratedthatPDSShadmuchhigheroralbioavailabilityandlongercirculationtimethanitsparentdrug.

简介：Thecalciumchannelblocker,verapamil,hasbeenshowntoreducescarformationbyinhibitingfibroblastadhesionandproliferationinvitro.Itwasnotclearwhethertopicalapplicationofverapamilaftersurgicalrepairofthenerveinvivocouldinhibittheformationofexcessivescartissue.Inthisstudy,therightsciaticnerveofadultSprague-DawleyratswastransectedandsuturedwithNo.10-0suture.Thestomawaswrappedwithgelfoamsoakedwithverapamilsolutionfor4weeks.Comparedwiththecontrolgroup(stomawrappedwithgelfoamsoakedwithphysiologicalsaline),theverapamilapplicationinhibitedthesecretionofextracellularmatrixfromfibroblastsinvivo,suppressedtypeIandIIIcollagensecretionandincreasedthetotalnumberofaxonsandthenumberofmyelinatedaxons.Thesefindingssuggestthatverapamilcouldreducetheformationofscartissueandpromoteaxongrowthafterperipheralnerverepair.

简介：vivoS1从外形上看就是一款主打女性和年轻人市场的产品。这次vivoS1在颜色上搭配了个性的波尔多红．装备一块4．0英寸SuperAMOLED屏幕，不管是从色彩、亮度和可视度上都表现的很出色。从步步高手机一直以来清新时尚的风格可以看出，这次又是视觉控出手的机会了。

简介：ActivinA，转变生长因素贝它(TGF-)的一个多功能的因素总科，被microglia和巨噬细胞主要生产，并且它的反煽动性并且支持inflammatory活动是与巨噬细胞功能有关的两个。然而，在vivo的剩余的巨噬细胞上的activinA的直接效果仍然保持不清楚。在现在的学习，结果显示出那activinA不仅不增加了并且IL-1版本，而且在vitro并且在vivo的鼠标腹巨噬细胞的支持的吞噬细胞的能力，而它没影响MHC我和MHCII表示。而且，我们显著地发现那activinAupregulatedCD14和CD68的表情，成熟巨噬细胞的标记，在在vitro并且在vivo的巨噬细胞的表面上。这些数据建议activinA能在vitro并且在vivo导致主要巨噬细胞成熟，但是不能经由调整涉及抗原的表示的MHC分子的表示触发获得的有免疫力的反应。

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简介：Theinvitroandinvivoeffectsofcornpeptides(CPs)preparedfromcornglutenmealbyproteolysiswithanalkalineproteaseandfractionsofCPsfromSephadexG-15andG-10columnsonactivitiesofalcoholdehydroge-nase(ADH)werestudied.TheresultsshowthatCPsandfraction3ofCPsfromSephadexG-10columnenhanceinvitroADHactivity.Furthermore,theinvitroacceleratingeffectofthefraction3ofCPsonADHactivitywassuperiortothatofglutathione,whichwasalsofoundeveninthepresenceofADHinhibitor,suchaspyrazole.Intheinvivoexperiments,theanimalswerefedwithdifferentdosagesofCPsandwithadoseofChinesedistilledspiritorally,andsacrificedforthemeasurementofADHactivity.InvivoexperimentalresultsindicatethatCPSenhancedhepaticADHactivities.TotestthesafetyofCPsashealthfood,30dfeedingtestwasperformed.NoobvioustoxiceffectsweredetectedintreatedWistarrats.

简介：Objective:TheaimofthisexperimentistostudytheeffectofthreemethodsofsurfacemodificationonthecorrosionresistanceofcommercialpureTitaniumwhenusedinoralenvironmentforhalfayear.Method:48specimensofpuretitaniumweremadeanddividedintofourgroupsrandomly,onegroupwasselectedrandomlyasGroupⅠ(controlgroup),theotherthreegroupsweretreatedbythreemethodsofsurfacemodificationindividually,GroupⅡ:heatingoxidationinair(400℃,30min.),GroupⅢ:anodization(45volts,10min.),GroupⅣ:TiNcoating(firingtemperature200℃,totalcoatingtime62min.).Sixedentulousvolunteerswithhealthyoralmucosaparticipatedintheinvivostudy.Onetestingpiecefromeachgroupwasselectedandfixedinthepolishedsurfaceofuppercompletedentures.Dynamicpolarizationcurvesweretracedwithelectrochemicalmethodafterthespecimenswereplacedeitherinoralcavityorinairfor6months.Results:Afterallspecimenswereused,Ecorralteredineverygroup,Ecorrfromhightolowwereinturn:TiNcoatinggroup＞heatingoxidationgroup＞anodizationgroup＞controlgroup,noobviouspassivepotentialEpandIpwasfoundincontrolgroup.HeatingoxidationinairexhibitedsimilarEptoanodization,butIpwasremarkablylowerthanthatofanodization;TiNcoatingshowedobviouslydifferentpolarizationcurvescomparedwithheating-oxidationgroupandanodizationgroup,Ecorrwaspositive,andnoEpandIpwasfound.Conclusion:Underpresentexperimentalcondition,allthethreetreatmentmethodscouldenhancecorrosionresistanceofpuretitaniuminoralenvironment,heatingoxidationinairexhibitedbetterresistancetocorrodethananodization,TiNcoatingpossessedthemostexcellentcorrosionresistance,evenafterexposedinoralconditionfor6months,therewaslittlechangeofcorrosionresistance.ThereforeTiNcoatingcouldbeadoptedtoimprovecorrosionresistanceofpuretitaniuminoralenvironment.

简介：AIM:Toinvestigatethedamagingeffectofhigh-intensityfocusedultrasound(HIFU)oncancercellsandtheinhibitoryeffectontumorgrowth.METHODS:MurineH22hepaticcancercellsweretreatedwithHIFUatthesameintensityfordifferentlengthsoftimeandatdifferentintensitiesforthesamelengthoftimeinvitro,thedeadcancercellsweredeterminedbytrypanbluestaining.TwogroupsofcancercellstreatedwithHIFUatthelowestandhighestintensitywereinoculatedintomice.Tumormasseswereremovedandweighedafter2wk,tumorgrowthineachgroupwasconfirmedpathologically.RESULTS:ThedeathrateofcancercellstreatedwithHIFUat1000W/cm2for0.5,1,2,4,8,and12swas3.11±1.21%,13.37±2.56%,38.84±3.68%,47.22±5.76%,87.55±7.32%,and94.33±8.11%,respectively.ApositiverelationshipbetweenthedeathratesofcancerceilsandthelengthofHIFUtreatmenttimewasfound(r=0.96,P＜0.01).ThedeathrateofcancercellstreatedwithHIFUattheintensityof100,200,400,600,800,and1000W/cm2for8swas26.31±3.26%,31.00±3.87%,41.97±5.86%,72.23±8.12%,94.90±8.67%,and99.30±9.18%,respectively.ApositiverelationshipbetweenthedeathratesofcancercellsandtheintensitiesofHIFUtreatmentwasconfirmed(r=0.98,P＜0.01).ThecancercellstreatedwithHIFUat1000W/cm2for8swereinoculatedintomiceexvivo.Thetumorinhibitoryratewas90.35%comparedtothecontrol(P＜0.01).IntheexperimentalgroupinoculatedwiththecancercellstreatedwithHIFUat1000W/cm2for0.5s,thetumorinhibitoryratewas22.9%(P＜0.01).Bypathologicalexamination,tumorgrowthwasconfirmedin8outof14mice(57.14%,8/14)inoculatedwiththecancercellstreatedwithHIFUat1000W/cm2for8s,whichwassignificantlylowerthanthatinthecontrol(100%,15/15,P＜0.05).CONCLUSION:HIFUiseffectiveonkillingordamageofH22hepaticcancercellsinvitroandoninhibitingtumorgrowthinmiceexvivo.

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