简介:摘要: 目的: 探讨微调平衡 2 号联合 TP 方案在晚期三阴性乳腺癌患者中的临床治疗效果。 方法: 集合 2017.3-2019.3 江阴中医院及无锡中医两院收治的 114 例晚期三阴性乳腺癌患者行对比实验,随机分组其为联合组及一般组,一般组行 TP 方案治疗,联合组则在 TP 方案基础上联合微调平衡 2 号方进行治疗,对比两组治疗效果。 结果: 联合组治疗有效率较一般组更佳,差异符合有统计学意义判定( P < 0.05 )。 结论: 微调平衡 2 号方联合 TP 方案治疗晚期三阴性乳腺癌患者较单一 TP 方案临床疗效更佳,可推广。
简介:摘要目的本研究探讨急性脑外伤患者心电图相关指标的变化及其与预后的关系。方法前瞻性收集2014年1月至2018年1月就诊的急诊脑外伤患者289例,最终入选219例及与相匹配的对照组220例,入院1 h及住院72 h行心电图,测算P波离散度(Pd)、校正后QT (QTc)、校正后QT离散度(QTcd )、校正后Tp-e间期(Tp-ec )、校正后Tp-e间期离散度(Tp-ecd )及Tp-e/QT比值,分别应用独立样本t检验和配对样本t检验比较脑外伤组第1天和对照组、第1天和第3天上述指标的变化,分析外伤组心电图指标与病情轻重及住院期间不良事件(MACE)的关系。结果脑外伤组患者第3天QTc、Tp-ec和Tp-e/QT较对照组及第1天均增加,差异有统计学意义(P均<0.05);格拉斯哥(GCS)评分中重度脑损伤患者Tp-ec、Tp-e/QT较评分为轻度者增大,差异有统计学意义[(150.48±16.58 )vs(130.14±11.86 ),P=0.006 ;(0.29±0.04)vs (0.23±0.03 ),P=0.030]。住院期间出现MACE组患者Tp-ec、Tp-e/QT较无MACE组增大[(149.76±12.52 )vs(128.84±12.47 ),P <0.001 ;(0.30±0.04 )vs (0.21±0.03),P <0.001]。结论急性脑外伤患者Tp-e和Tp-e/QT与病情严重程度相关,一定条件下可作为短期预后的评价和预测指标。
简介:AbstractBackground:The association between free triiodothyronine (FT3) and long-term prognosis in dilated cardiomyopathy (DCM) patients has not been evaluated. The purpose of this study was to determine whether the level of FT3 could provide prognostic value in patients with DCM.Methods:Data of consecutive patients diagnosed with DCM were collected from October 2009 to December 2014. FT3 was measured by fluoroimmunoassay. Other biochemical markers, such as free thyroxin (FT4), thyroid-stimulating hormone, red blood cell, hemoglobin, blood urea nitrogen, and serum creatinine, were tested at the same time. Follow-up was performed every 3 months. The primary endpoint was all-cause mortality. Pearson analysis was used to evaluate the correlation of FT3 and other lab metrics with DCM patients’ prognosis. The association of long-term mortality in DCM and FT3 was compared using Cox hazards model.Results:Data of 176 patients diagnosed with DCM were collected. Of them, 24 patients missed FT3 values and six patients were lost to follow-up. Altogether, data of 146 patients were analyzed. During the median follow-up time of 79.9 (53.5-159.6) months, nine patients lost, 61 patients died (non-survival group), and 85 patients survived (survival group). FT3 was significantly lower in non-survival group than that in survival group (3.65 ± 0.83 pmol/L vs. 4.36 ± 1.91 pmol/L; P = 0.003). FT3 also showed a significantly positive correlation with red blood cell and hemoglobin, negatively correlated with age, blood urea nitrogen and serum creatinine (P < 0.05), respectively. Patients in the group of lower FT3 levels (FT3 ≤ 3.49 pmol/L) suffered from a higher risk of all-cause mortality (P for log-rank = 0.001). In multivariate Cox regression analysis, FT3 level was significantly associated with all-cause mortality (hazard ratio: 0.70, 95% confidence interval 0.52-0.95, P for trend = 0.021).Conclusion:Low levels of FT3 were associated with increased all-cause mortality in patients with DCM.
简介:摘要:本文针对学生不易掌握导数含参数问题中参数该如何分类的问题,通过对几个典型问题的探究,结合流程图来对参数的分类方法和含参数问题的求解步骤来进行总结,形成解决此类问题的模式化解题方法。用流程图来体现参数的分类方法,直观明了,易理解,将解题思想流程化,易操作。
简介:摘要目的通过分析不同程度乳糜血浆中TP-Ab检测的影响因素,探讨乳糜血浆检测结果的可靠性。方法在阴性乳糜血浆中加入定量TP-Ab阳性血液,采用ELISA法检测乳糜血浆中TP-Ab。结果乳糜指数分别为2、3、4、5、6、8及>8与无乳糜指数(≤1)(1.876±0.209)比较,(±s)分别为(1.854±0.264)、(1.775±0.285)、(1.748±0.144)、(1.650±0.276)、(1.846±0.225)、(1.841±0.480)及(1.670±0.474),不同乳糜程度血浆TP-Ab检测结果差异无统计学意义(均P>0.05)。不同乳糜程度血浆放置时间不同,TP-Ab检测结果有差异:放置时间延长,检测结果升高,第1天与第3天比较,(±s)分别为(1.876±0.209)和(1.919±0.194),3 d内检测结果差异无统计学意义(P>0.05);放置第5天,仅乳糜指数2和4的(±s)为(1.780±0.342)及(1.801±0.286),差异无统计学意义(P>0.05),其他不同乳糜指数血浆(±s)分别为(1.697±0.280)、(1.934±0.363)、(2.156±0.308)、(2.013±0.470)及(1.871±0.526),差异有统计学意义(均P<0.05);第7天和第10天,检测结果差异均有统计学意义(均P<0.05)。结论不同程度乳糜血浆TP-Ab检测结果无差异;乳糜血浆3 d内检测TP-Ab结果可靠,5 d后检测结果差异有统计学意义。
简介:摘要:近年来, 石油炼化及煤化工行业的 加氢裂化装置 越来越多,装置内 的反应炉管及高温、高压、临氢管道多选用 奥氏体不锈钢 TP347 材料。然而工程中 TP347 材料焊接时非常容易出现裂纹,此种材料的焊接脆性是重要的隐性危害。因此,确定合适的焊接方法、合理的焊接工艺,并控制铁素体含量成为焊接过程中的关键。
简介:AbstractPurpose:To establish a severe blast lung injury model of goats and investigate the feasibility of lung ultrasonic score in the evaluation of blast lung injury.Methods:Twenty female healthy goats were randomly divided into three groups by different driving pressures: 4.0 MPa group (n = 4), 4.5 MPa group (n = 12) and 5.0 MPa group (n = 4). The severe blast lung injury model of goats was established using a BST-I bio-shock tube. Vital signs (respiration, heart rate and blood pressure), lung ultrasound score (LUS), PO2/FiO2 and extravascular lung water (EVLW) were measured before injury (0 h) and at 0.5 h, 3 h, 6 h, 9 h, 12 h after injury. Computed tomography scan was performed before injury (0 h) and at 12 h after injury for dynamic monitoring of blast lung injury and measurement of lung volume. The correlation of LUS with PaO2/FiO2, EVLW, and lung injury ratio (lesion volume/total lung volume*100%) was analyzed. All animals were sacrificed at 12 h after injury for gross observation of lung injury and histopathological examination. Statistical analysis was performed by the SPSS 22.0 software. The measurement data were expressed as mean ± standard deviation. The means of two samples were compared using independent-sample t-test. Pearson correlation analysis was conducted.Results:(1) At 12 h after injury, the mortality of goats was 0, 41.67% and 100% in the 4.0 Mpa, 4.5 MPa and 5.0 MPa groups, respectively; the area of pulmonary hemorrhage was 20.00% ± 13.14% in the 4.0 Mpa group and 42.14% ± 15.33% in the 4.5 MPa group. A severe lung shock injury model was established under the driving pressure of 4.5 MPa. (2) The respiratory rate, heart rate, LUS and EVLW were significantly increased, while PaO2/FiO2 was significantly reduced immediately after injury, and then they gradually recovered and became stabilized at 3 h after injury. (3) LUS was positively correlated with EVLW (3 h: r = 0.597, 6 h: r = 0.698, 9 h: r = 0.729; p < 0.05) and lung injury ratio (12 h: r= 0.884, p < 0.05), negatively correlated with PaO2/FiO2 (3 h: r =-0.871, 6 h: r =-0.637, 9 h: r =-0.658; p < 0.05).Conclusion:We established a severe blast lung injury model of goats using the BST-I bio-shock tube under the driving pressure of 4.5 MPa and confirmed that ultrasound can be used for quick evaluation and dynamic monitoring of blast lung injury.
简介:摘要:目的: 实验将针对 TP 化疗治疗卵巢癌的患者实施针对性护理支持,进一步为患者的康复治疗提供支持。 方法: 实验选取了 201 9 年 5 月~ 20 20 年 4 月 收治的卵巢癌 患者作为研究的对象。通过回顾式分析 对 62 例患者采用数字随机 分 组,对照组患者采用常规护理措施,观察组则为针对性护理措施,归纳总结护理方案。 结果: 从护理质量上看,观察组患者的不良反应发生率为 16.2% ( 5/31 ) ,对照组为 35.5% ( 11/31 ) % , 组间对比差异较为显著,具有统计学意义( P < 0.05 )。与此同时,护理后生活质量的调查上,观察组患者的评分高于对照组,差异具有统计学意义。 结论: 采用针对性护理策略,对于实施 TP 化疗治疗卵巢癌患者的病情协助具有积极作用,能够提升生活质量,降低不良事件的发生率,为患者治疗保驾护航。
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简介:【摘要】:目的:探究硬化疾病病人进行生化检验及对CHE、ALB、TP水平值的影响价值。方法:纳入硬化疾病病人59例和健康体检人员59例为研究对象,就诊时间2019年2月~2020年7月。将59例肝硬化疾病病人,设为α组;将59例健康体检人员设为β组。2组均进行生活检验。探究2组受检者丙氨酸转氨酶ALT、血清总胆红素TBil、门冬氨酸氨基转移酶AST水平值、血清胆碱酯酶CHE水平值、白蛋白ALB水平值、血清总蛋白测定TP水平值。结果:α组丙氨酸转氨酶ALT水平值(57.83±11.28)U/L、血清总胆红素TBil水平值(87.11±9.05)Umol/L、门冬氨酸氨基转移酶AST水平值(97.65±11.32)u/L,明显高于β组的(14.78±1.32)U/L、(11.89±4.17)umol/L、(14.71±2.36)U/L。(P<0.05);α组血清胆碱酯酶CHE水平值(2018.58±92.64)U/L、白蛋白ALB水平值(21.45±2.24)g/L、血清总蛋白测定TP水平值(53.17±7.13)umol/L,均明显低于β组的(8915.36±114.13)U/L、(43.13±5.09)g/L、(76.42±9.14)umol/L(p
简介:摘要目的观察脑脊液TP53基因突变在肺癌相关癌性脑膜炎中的作用。方法选取2015年12月至2018年12月就诊于河北医科大学第二医院的35例确诊为肺癌相关癌性脑膜炎患者进行回顾性分析。所有患者均行脑脊液二代测序得出TP53基因为突变型或野生型,其中TP53基因突变型患者有23例,TP53基因野生型患者有12例。观察两组间患者的临床特征、脑脊液常规、生化、KPS评分及总生存期间的差异。结果两组在临床表现上均以头痛、恶心呕吐症状为主;两组间在脑脊液压力、白细胞、生化及KPS评分方面均无统计学意义;TP53基因突变型组原发灶确诊至脑膜转移平均时间明显短于TP53基因野生型组(5.79个月比25.5个月);TP53基因突变型组中患者自原发灶确诊至观察终点的中位生存时间为19.77个月,TP53基因野生型组中患者自原发灶确诊至观察终点的中位生存时间为88.73个月,差异有统计学意义(P=0.043)。结论肺癌相关癌性脑膜炎患者的脑脊液中可检测到抑癌基因TP53的基因突变,存在该基因突变的患者较早发生脑膜转移且中位生存期较短。
简介:【摘要】目的:探讨院前急救护理路径在脑卒中患者院前急救中的作用。方法:选择 2016年 9月 -2017年 1月期间呼救中心接收的 260例脑卒中患者,根据呼救先后顺序分为观察组 130例以及对照组患者 130例。对照组脑卒中患者按照常规护理进行救治,观察组脑卒中患者则根据院前急救护理路径进行救治,比较两组患者的治疗结局。结果:观察组脑卒中患者的呼救至救护车到达时间为 24.61±10.14min,对照组脑卒中患者呼救至救护车达到时间为 30.62±14.15min, P< 0.05;观察组脑卒中患者入院接受专科治疗时间为 38.68±10.49min,对照组脑卒中患者入院接受专科治疗时间为 46.72±12.49min, P< 0.05;观察组脑卒中患者的致残率和致死率分别为 9( 6.92%)、 5( 3.85%)较对照组患者 16( 12.31%)、 13( 10%)有明显的优势, P< 0.05。结论:脑卒中患者采用院前急救护理路径有效的缩短患者获得急救时间间隔,阻止病情的恶化,改善不良治疗结局。
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