简介:摘要:习近平总书记强调:“要把人才工作抓好,让人才事业兴旺起来,国家发展靠人才,民族振兴靠人才。” 2009年以来,全国各地不断加强综合应急救援力量建设,相继依托消防救援队伍成立了综合应急救援总队、支队和大队,消防救援队伍组建了地震救援重型和轻型搜救队。但是,地震救援人才建设仍然存在结构布局不尽合理、人才培养机制不健全,还存在地震救援人才建设时认识不足、培训不够、主动意识不强等问题,严重影响了消防救援队伍地震应急救援作战效能。
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简介:摘要:K4往复式给煤机在使用中存在减速机输出轴曲柄连接销轴发生断裂的问题以及对轮销轴断裂的问题,对安全生产造成中断浪费人力物力,对其进行改造克服这两点问题,自制压板通过螺栓压紧曲柄增大摩擦力,从而减少曲柄连接销轴发生断裂;改变对轮连接方式,利用废旧皮带加工成特殊形状连接对轮凸缘,利用皮带的韧性和强度来传动,杜绝了对轮销轴断裂的问题。
简介:AbstractObjective:The immune system is involved in the pathogenesis of schizophrenia; here, we aimed to explore the relationship of cytotoxic T lymphocyte antigen 4 (CTLA4) with schizophrenia.Methods:CTLA4 gene structure was first analyzed, and then rs231779, rs733618, rs231775 and rs3087243 were selected as tag single nucleotide polymorphisms for the linkage disequilibrium blocks in CTLA4 in the Chinese Han population to study expression quantitative trait loci of CTLA4 gene in normal brain tissue. Additionally, membrane CTLA4 (mCTLA4) and soluble CTLA4 (sCTLA4) mRNA expression levels were evaluated in peripheral blood mononuclear cells from 65 first-episode schizophrenia patients and 61 healthy controls. This study was approved by the Bioethics Committee of corresponding research institutes (approval No. 20150016) on March 6, 2015 and the principles of the Declaration of Helsinki.Results:After applying Bonferroni correction to the P values, only the minor C allele of rs733618 was significantly associated with increased expression of total CTLA4 (PBonf.= 0.019), but not mCTLA4 (PBonf. = 0.115), in the hippocampus. The sCTLA4 expression was significantly decreased in the peripheral blood mononuclear cells of schizophrenia patients compared with healthy controls, while mCTLA4 was not.Conclusion:These results suggest that the soluble form of CTLA4 may be associated with schizophrenia and that lower sCTLA4 expression may increase the risk of developing schizophrenia.