简介:摘要:本文主要阐述37Z叶片的工艺设计方案的制定、前期验证和后期批量生产中存在的问题,并对工艺进行改进提升。利用不同颜色的定位模块将冷铁定位,以解决铸件缩孔、表面质量差的问题。通过倾角浇注和增加铁水静置时间等方法,解决了铸件表面线性缺陷的关键技术问题,并取得了良好的经济效益。
简介:摘要:为解决数控龙门加工中心垂直轴(Z轴)存在断电后自行下溜现象,对机械机构加以改造,外加一个制动器达到迅速制动的效果。本方案虽然是在运行年限比较长的数控龙门加工中心成功运用,但也可以推广到其他垂直往复运动需要迅速制动的设备上,具有一定的推广价值。
简介:TheZ-backlighterlaserfacilityprimarilyconsistsoftwohighenergy,high-powerlasersystems.Z-Beamletlaser(ZBL)(Ramboetal.,Appl.Opt.44,2421(2005))isamulti-kJ-class,nanosecondlaseroperatingat1054nmwhichisfrequencydoubledto527nminordertoprovidex-raybacklightingofhighenergydensityeventsontheZ-machine.Z-Petawatt(ZPW)(Schwarzetal.,J.Phys.:Conf.Ser.112,032020(2008))isapetawatt-classsystemoperatingat1054nmdeliveringupto500Jin500fsforbacklightingandvariousshort-pulselaserexperiments(seealsoFigure10forafacilityoverview).Withthedevelopmentofthemagnetizedlinerinertialfusion(MagLIF)conceptontheZ-machine,theprimarybacklightingmissionsofZBLandZPWhavebeenadjustedaccordingly.Asaresult,wehavefocusedourrecenteffortsonincreasingtheoutputenergyofZBLfrom2to4kJat527nmbymodifyingthefiberfrontendtonowincludeextrabandwidth(forstimulatedBrillouinscatteringsuppression).TheMagLIFconceptrequiresawell-defined/behavedbeamforinteractionwiththepressurizedfuel.HencewehavemadegreateffortstoimplementanadaptiveopticssystemonZBLandhaveexploredtheuseofphaseplates.WearealsoexploringconceptstouseZPWasabacklighterforZBLdrivenMagLIFexperiments.Alternatively,ZPWcouldbeusedasanadditionalfusionfuelpre-heaterorasatemporallyflexiblehighenergypre-pulse.AlloftheseconceptsrequiretheabilitytooperatetheZPWinananosecondlong-pulsemode,inwhichthebeamcanco-propagatewithZBL.Someoftheproposedmodificationsarecompleteandmostofthemarewellontheirway.
简介:Prostatecancergene3(PCA3,alsoknownasDD3)isanewbiomarkerthatcouldimprovetheaccuracyofprostatecancerdiagnosis.Itisagreatbiomarkerwithfairlyhighspecificityandsensitivity.Theincidenceofprostatecancerisrisingsteadilyinmostcountries.Thecommonlyusedprostate-specificantigen(PSA)testoncegavepeoplehopeforearlydiagnosisofprostatecancer.However,thelowspecificityofthePSAtesthasresultedinalargenumberofunnecessarybiopsiesandovertreatment.Duringthepastdecade,manynewprostatecancerbiomarkershavebeenfound.Amongthese,PCA3isthemostpromising.Duetoitsgreatperformanceindistinguishingprostatecancerfromotherprostateconditions,PCA3couldlikelybeappliedforearlydiagnosisofprostatecancer,patientfollow-up,prognosisprediction,andtargetedtherapy.Afteryearsofresearch,wehaveobtainedsomeknowledgeaboutthesequenceofPCA3gene.WehavealsodeterminedtherelationshipbetweenPCA3andtheproliferationofprostatecancercellsandlearnedsomeinformationabouthowPCA3affectstumor-relatedgenesandproteins.APCA3scorehasbeencreated,andithasbeenusedinavarietyofstudies.SomeresearchershaveevenappliedPCA3totargetedtherapyandobtainedagoodeffectinvitro.Thisreviewdescribesthecurrentstateofresearch,andexploresthefutureprospectsforPCA3.更多还原
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简介:AbstractBackground:Obstetric hemorrhage is a major cause of maternal death during cesarean delivery. The objective of this retrospective observational study was to evaluate the efficacy and safety of intra-operative cell salvage (IOCS) in cesarean section.Methods:We included a total of 361 patients diagnosed with central placenta previa who underwent cesarean section from May 2016 to December 2018. In this study, 196 patients received autologous transfusion using IOCS (IOCS group) and 165 patients accepted allogeneic blood transfusion (ABT group). Propensity score matched analysis was performed to balance differences in the baseline variables between the IOCS group and ABT group. Patients in the IOCS group were matched 1:1 to patients in the ABT group.Results:After propensity score matching, 137 pairs of cases between the two groups were successfully matched and no significant differences in baseline characteristics were found between the IOCS group and ABT group. Patients in the IOCS group were associated with significantly shorter length of hospital stay, compared with ABT group (8.9 ± 4.1 days vs. 10.3 ± 5.2 days, t= -2.506, P = 0.013). The postoperative length of hospital stay was 5.3 ± 1.4 days for patients in the IOCS group and 6.6 ± 3.6 days for those in the ABT group (t = -4.056, P < 0.001). The post-operative hemoglobin level in the IOCS group and ABT group was 101.3 ± 15.4 and 96.3 ± 16.6 g/L, respectively, which were significantly different (t= 2.615, P= 0.009). Allogeneic red blood cell transfusion was significantly lower at 0 unit (range: 0–11.5 units) in the IOCS group when compared with 2 units (range: 1–20 units) in the ABT group (P < 0.001).Conclusions:This retrospective observational study using propensity score matched analysis suggested that IOCS was associated with shorter length of postoperative hospital stay and higher post-operative hemoglobin levels during cesarean delivery.
简介:AbstractObjective:To compare and correlate the efficacy of the NOSE score & the VAS score in determining the symptomatic benefit in patients undergoing septoplasty.Materials and methods:Eighty patients with deviated nasal septum undergoing septoplasty were included in the study. NOSE score & VAS score (out of 100) was documented before and after surgery. Results were correlated and compared statistically.Results:In the NOSE score, the most bothersome symptom was trouble breathing through the nose (85.83); followed by Nasal obstruction or blockage (82.50). Wilcoxon test showed significant improvement with NOSE score and VAS score in all patients at 1 month and 3 months. Spearman’s coefficient showed a positive correlation between the two, though the score improvement and patient satisfaction rate was significantly high with NOSE score.Conclusions:NOSE score and the VAS score both provide effective framework for evaluating treatment responses after septoplasty. However, the NOSE score showed higher improvement and better patient satisfaction rate when used to measure of nasal obstruction as compared to the VAS score.
简介:目的:研究损伤严重程度感知(ISP)评分法在测试急性挥鞭样损伤患者中的复测可重复性。方法:在基层保健中心连续对急性阶段患急性挥鞭样损伤患者采用ISP评分。ISP是一种通过数字等级进行评分,其测量范围从0到10,受试者被要求指出他们自认为的受伤严重程度。0代表'无损伤',10代表'严重且永久性损伤'。利用ISP问卷对同一批受试者在招募完成时及7天后进行评分。复测可重复性由一致百分率和在两个时间点进行的Kappa分析进行计算。锚定两端分别标记为'没有损伤'(0)和'严重损伤,可能是永久性损伤'(10)。结果:实验包括94名研究对象(34名男性,60名女性,平均年龄为40.6±10.0岁,范围19-60岁),在刚招募时JSP平均得分为4.9±1.7(评分在2-9之间),一周后ISP平均得分为5.1±2.1(评分在2-9之间)。在ISP的两次重复测量中百分比一致率为86%,Kappa系数为0.79。结论:这项研究表明ISP复测可重复性在预后研究中偏倚风险较低。ISP评分法在急性挥鞭样损伤患者的流行病学研究中具有相当高的可靠性。
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简介:(4)捣蛋鬼变成大英雄“你们这是干什么?”严老师和教导郎主任的声音几乎同时爆炸在空中。