摘要
【摘要】 目的：探讨托吡酯联合丙戊酸钠治疗小儿癫痫的临床效果。方法： 80例患儿均为笔者所在医院 2017年 12月 -2018年 12月收治的小儿癫痫病例，按照入院顺序单号为对照组，双号为观察组，每组 40例。对照组患儿单纯接受托吡酯治疗，观察组患儿接受托吡酯联合丙戊酸钠治疗。治疗结束后，观察两组患儿的疗效，并就治疗期间不良反应发生情况展开分析。同时，随访 1年，统计两组患儿癫痫复发情况。结果：治疗 3～ 6个月后，观察组患儿治疗总有效率显著高于对照组，差异有统计学意义（ P<0.05）。治疗期间，观察组患儿与对照组患儿不良反应发生率比较，差异无统计学意义（ P>0.05）。随访 1年，观察组患儿癫痫复发 1例，显著低于对照组的 4例，差异有统计学意义（ P<0.05）。结论：针对小儿癫痫可行托吡酯联合丙戊酸钠治疗，不但能显著改善小儿癫痫症状，不良反应较少，安全性较高，且可有效防止复发，值得推广。
【关键词】 托吡酯； 丙戊酸钠； 小儿癫痫； 不良反应； 复发率
[abstract] Objective: To investigate the clinical effect of topiramate combined with sodium valproate in the treatment of epilepsy in children. Methods: 80 cases of children with epilepsy were treated in our hospital from December 2017 to December 2018. According to the order of admission, the single group was the control group and the double group was the observation group, 40 cases in each group. The control group received topiramate only, while the observation group received topiramate combined with sodium valproate. After the treatment, the curative effect of the two groups was observed, and the occurrence of adverse reactions during the treatment was analyzed. At the same time, follow-up for 1 year, statistics two groups of children with epilepsy recurrence. Results: After 3 to 6 months of treatment, the total effective rate of the observation group was significantly higher than that of the control group (P < 0.05). During the treatment period, there was no significant difference in the incidence of adverse reactions between the observation group and the control group (P > 0.05). Following up for one year, 1 case of epilepsy recurrence in the observation group was significantly lower than that in the control group (4 cases), the difference was statistically significant (P < 0.05). CONCLUSION: Topiramate combined with sodium valproate is feasible for the treatment of epilepsy in children. It can not only significantly improve the symptoms of epilepsy in children, with fewer adverse reactions and higher safety, but also effectively prevent recurrence, which is worthy of promotion.
出版日期
2019年12月17日（中国期刊网平台首次上网日期，不代表论文的发表时间）
