ObjectivesToanalyzethechangesofvasoactivesubstancesoriginatedfromendotheliuminpatientswithunstableanginapectoristreatedbymodifiedthrombolytictherapyandexplorethemechanismsofthedrugtotreatunstableanginapectoris.Methods120patientswithunstableanginapectoriswhowerenotwellresponsedtocommonmedicationwerestudied.TheirECGstresstestswereabnormalandtherewereischemicchangesinHolter.Urokinase300,000Uwasaddedin100mlnormalsalineandinjectedwithin30minonceadayfor3days.300mgaspirinwasadministratedadaybeforeandduringurokinaseapplications.Beforeandafterurokinasetreatments,endothelin-1,plasmatissueplasminogenactivatoranditsinhibitor-1weredetermined.ResultsComparedwithpretreatments,aftertreatments,theactivitiesoftissueplasminogenactivatorincreased,endothelin-1andtheinhibitor-1decreased.Thechangesweresignificant.ConclusionsModifiedthrombolytictherapycanregulatethevasoactivesubstancesoriginatedendotheliuminpatientswithunstableanginapectoris.Themajorsubstancesincludeendothelin-1,plasmatissueplasminogenactivatorandinhibitor-1.Thismechanismmaysuggestthaturokinasecantreatcoronaryheartdiseaseeffectively.
