简介：T助手17(Th17)房间处于生理的条件有规章、保护的角色。Th17子集和cytokineinterleukin-17A(IL-17A)在某些自体免疫的疾病，癌症的几种类型和allograft拒绝的致病被含有。然而，在母亲/胎儿的接口的Th17房间的角色仍然保持未知。这里，我们证明Th17房间在蜕膜是在场的并且基于细胞内部的cytokine分析在10临床上正常的怀孕的外部血被增加。我们的结果在在人支撑怀孕建议Th17房间的一个潜在的角色。而且，我们证明蜕膜的stromal房间(DSC)然而并非trophoblast房间招募外部Th17房间进由secretingCCL2的蜕膜。招募的Th17房间支持增长和侵略并且在怀孕的第一个三个月期间由secretingIL-17禁止人的trophoblast房间的apoptosis。这些调查结果在控制母亲胎儿的关系和胎盘开发为Th17房间显示一个新奇角色。

简介：Mesenchymalstromalcells(MSCs)areadultmultipotentstemcellsresidingaspericytesinvarioustissuesandorganswheretheycandifferentiateintospecializedcellstoreplacedyingcellsanddamagedtissues.Thesecellsarecommonlyfoundatinjurysitesandintumorsthatareknowntobehavelike'woundsthatdonotheal.'Inthisarticle,wediscussthemechanismsofMSCsinmigrating,homing,andrepairinginjuredtissues.WealsoreviewanumberofreportsshowingthattumormicroenvironmenttriggersplasticitymechanismsinMSCstoinducemalignantneoplastictissueformation,maintenance,andchemoresistance,aswellastumorgrowth.TheantitumorpropertiesandtherapeuticpotentialofMSCsarealsodiscussed.

简介：前列腺癌症(PCa)在外部地区(PZ)主要发生，是众所周知的，而良性的prostatic增生(BPH)典型地在转变地区发展。识别位于带的差别下面的可能的机制，我们比较了房间面对性荷尔蒙在一根PCa上皮的房间线(PC3)上从外部地区(PZsc)和转变地区(TZsc)导出的前列腺stromal的效果。首先，当房间与dihydrotestosterone(DHT)和β被对待时，我们观察到雄激素受体(AR)mRNA更高度比TZsc在PZsc被表示；-oestradiol(E2)(P<；0.05)。由ELISA，我们从PZsc和TZsc在肽生长因素的分泌物寻找了差别。我们发现那keratinocyte生长因素(KGF)分泌物与增加DHT的集中增加了(P<；0.01)并且比TZsc在PZsc是更高的。在有DHT正E2的治疗下面，PZsc分泌了更多的转变生长factor-β；1(TGF-β；1)与TZsc，而是这个模式被颠倒房间什么时候仅仅与E2被对待比。与增加DHT的集中，像胰岛素的生长factor-1(IGF-1)分泌物在PZsc增加了，但是在TZsc减少了。为了推进，在PC3房间上描绘PZsc和TZsc的效果，我们开发了一个coculture模型并且执行了MTT试金，西方的污点分析和即时RT-PCR。我们发现PZsc比TZsc更好支持了PC3房间增长和前进，特别地当与10 对待时；加10 的nmoll−1DHT；nmoll−1E2。在结论，我们的数据建议PZsc可以有一个更大的能力经由性荷尔蒙调整的生长因素比TZsc导致PCa开发和前进。这些调查结果提供在前列腺疾病位于带的差别下面的可能的机制，它可以为PCa为新奇治疗学的目标帮助搜索。

简介：前列腺癌症(PCa)是年龄相关的疾病，并且stromal微型环境在prostatic起一个重要作用恶意的前进。然而，在在年轻、旧的织物在场的前列腺stromal房间的差别仍然是阴暗的。我们从改变年龄的施主的正常prostatic外设地区(PZ)建立了主要有教养的stromal房间并且从旧施主发现那有教养的stromal房间(PZ旧)更多被扩大并且比那些多角形从年轻施主(PZ年轻)。基于immunocytochemical和ultrastructural分析，而且，stromal房间的部件与增加施主年龄从成纤维细胞的一个多数改变了到成纤维细胞和myofibroblasts的混合物。用一在vitro文化系统三维，我们发现PZ旧的stromal房间能提高cocultured的增长，迁居和侵略良性的BPH-1和PC-3房间。用一在里面vivo织物再结合系统，我们也发现PZ旧的stromal房间是比在由高经过的BPH-1房间支持瘤形成的PZ年轻的房间更有效的(>；100)并且PC-3房间。到这些的可能的机制完成的探查，我们执行了cDNAmicroarray分析并且在PZ旧的房间介绍了509upregulated基因和188downregulated基因。在改变的基因之中，我们发现了基因为能够影响邻近的上皮的房间的paracrine因素的一个子集编码；这些包括hepatocyte生长因素(HGF)，成纤维细胞生长因素5(FGF5)，像胰岛素的生长因素2(IGF2)，像胰岛素的生长因素绑定蛋白质4(IGFBP4)，IGFBP5和矩阵metallopeptidase1(MMP1)。在这些基因的表示的变化被量的即时聚合酶链反应(PCR)进一步证实，西方的弄污和连接酶的immunosorbent试金。总的来说，我们的调查结果显示从旧施主的前列腺PZ的stromal房间是比从在支持邻近的上皮的房间的恶意的过程的年轻施主的类似的房间更活跃的。在为PCa的预防的新潜在的策略的这发现提示。

简介：ObjectiveTo评估在里面vitro并且在脂肪质导出stromal房间(ASC)的vivoosteogenic能力，.MethodASCs从新西兰白兔子被孤立并且由染色的碱的磷酸酶(高山)决定了，vonKossa染色并且茜素红染色。osteogenic区别的一些特定的标记包括高山，osteocalcin(OCN)，osteopontin(OPN)被反向的抄写聚合酶链反应(RT-PCR)检验。在vivo，demineralized骨头矩阵(DBM)-ASCscomposites被植入进在纵的中线的每个方面创造的兔子calvarial缺点。在6个星期以后，transplants的histo逻辑性质是analyzed.ResultsASCs成功地被导致进成骨。染色的高山，vonKossa染色和茜素红染色显示出积极结果。高山，OCN和OPN的表情在osteogenic媒介在耕作以后在ASC被检测。广泛的新骨头在与DBM-ASCscomposites.ConclusionASCs移植的缺点被观察有潜力区分进osteogenic系和DBM-ASCs构造是为在骨头缺点的新生的一个有希望的方法。

简介：Objective:Tofurtherinvestigatetheosteogenicpotentialofrabbitmarrowstromalstemcellsculturedinvitro.Methods:Rabbitmarrowstromalstemcellswereisolatedbydensitygradientcentrifugationmethodandamplifiedintheflasks,usingtheosteogenicinducingconditions(OGC)astheculturemedia.Theosteogenicpotentialofmarrowstromalstemcellswereinvestigatedbymeansofbone-seekingfluorescenc(tetracycline)labeling,AlizarinredS(ARS)staining,Alcianblue-Siriusred(AS)staining,andscanningelectronmicroscope.Results:Afterbeingpassaged,themarrowstromalstemcellsincreasedinnumber,becameconfluentandformedmulti-layerstructure.Thestromalstemcellsexcretedinnumerabletinygranules,heapinguponthecellbodyandmerginggraduallyintofoggysubstances.Thesefoggysubstanceskeptonenlargingandformedround,oval,orflake-likenodules.Thesenodulesrevealedbrightgoldenyellowfluorescenceunderfluorescencemicroscopewhenlabeledwithtetracycline.HistochemicalstudywithspecificnewbonestainingwithARSrevealedpositivecalciumreaction,bothdenotingthattheywerenewlyformedbonetissues.AftertheywerestainedwithAS,collagenandacidmucopolysaccharidewereshown.Underscanningelectronmicroscope,threetypesofcellswithdifferentconfigurationswerefound.Theywereglobularcells,spindle-shapedcellsandpolygonalorpolygonalcells.Granuleswereexcretedfromthecellsandheapeduponthecellbody.Needle-shapedandirregularlyrectangularcrystalsalsoappearedandagglomeratedwiththegranulestoformnodulesandtrabecula-likeorflake-likestructures.Conclusions:Sequenceofeventsofboneformationbyrabbitmarrowstromalstemcellsculturedinvitroisfullydepictedandconfirmed,whichprovidesthefoundationforfurtherinvestigatingthemechanismsofosteoblastdifferentiationfrommarrowstromalstemcellsandthepossibleapplicationinorthopaedics.

简介：AbstractObjective:The maternal-fetal interface undergoes dynamic changes to allow the fetus to grow and develop in the uterus. The interaction between decidual γδ T cells and trophoblasts plays a pivotal role during successful pregnancy; however, their physiological functions in early-term human pregnancy are still not completely illustrated. This study was undertaken to illustrate the functional roles of CXCL16/CXCR6 to prevent pregnancy loss via the crosstalk between decidual γδ T cells and HTR8/SVneo trophoblast cells.Methods:The percentile of CXCR6+ γδ T cells in the peripheral blood from normal female and recurrent spontaneous abortion (RSA) patients was analyzed by flow cytometry. The expression of CXCR6 was detected in decidual immune cells via flow cytometry, and the expression of CXCL16 was analyzed in HTR8/SVneo trophoblast cells and lentivirus (LV)-HTR8/SVneo trophoblast cells via enzyme-linked immunosorbent assay. Reverse transcriptase-polymerase chain reaction was used to verify the expression of the CXCL16 gene in LV-HTR8/SVneo trophoblast cells. Expression of granzyme B and cytokines and proliferation of decidual γδ T cocultured with HTR8/SVneo trophoblast cells were analyzed by flow cytometry. Invasion of HTR8/SVneo trophoblast cells was assessed via Matrigel transwell assay. Adoptive transfer was induced in vivo further to illustrate that the normal expression of CXCL16/CXCR6 could prevent pregnancy loss.Results:The percentile of CXCR6+ γδ T cells in the peripheral blood from RSA patients was lower than normal pregnancies. The expression of CXCR6 was highest in the decidual γδ T cells among decidual immune cells, and the expression of CXCL16 increased as the amount of HTR8/SVneo trophoblast cells increased. Expression of granzyme B in the decidual γδ T cells was downregulated by cocultured with HTR8/SVneo cells dependent of CXCL16, and HTR8/SVneo trophoblast cells induced the Th2 cytokines production in the decidual γδ T cells. Both the expression of CXCR6 in the decidual γδ T cells and proliferation of the decidual γδ T cells were promoted by HTR8/SVneo trophoblast cells. On the other hand, decidual γδ T cells enhanced the invasion of HTR8/SVneo trophoblast cells and thus promoted embryo implantation. In vivo study was taken further and shown that low expression of CXCL16/CXCR6 results in pregnancy loss because of dialog disorder between decidual γδ T cells and trophoblasts.Conclusions:Low expression of CXCL16/CXCR6 results in pregnancy loss because of the dialog disorder between decidual γδ T cells and trophoblasts, and it showed a light on the effective strategy of adoptive transfer of CXCR6+ γδ T cells on the treatment of RSA. This observation provides a scientific basis on which a potential strategy can be applied to the early-detect and treatment of RSA.

简介：Tostudytheosteogenicabilityoftissue-engineeredboneconstructedbycompoundingzinc-sin-teredbovinecancellousbonewithrabbitmarrowstromalcells(MSCs)invivo,thezinc-sinteredbovinecancellousboneofbeta-tricalciumphosphate(TCP)typewaspreparedbysinteringthefreshcalfcancellousbonetwiceandthenloadingitwithzinc-ion.TherabbitMSCswerecultured,inducedandseededontothezinc-sinteredbovinecan-cellousbones.Thetissue-engineeredboneswerethenimplantedintotherabbits'bockmuscles.Thenewlyformedbonetissueswereobservedbyhistologicalmethodsandtheareasofnewosseoustissuesweremeasuredattheendofthe4thand8thweek.Thezinc-sinteredbovinecancellousbonesalonewereimplantedontheothersideascontrol.TheosteogenicactivityofMSCswasidentifiedbyalkalinephosphatase(ALP)stainingandcalcificationnodchi-nalizarinstaining.Attheendof4thweek,asmallamountofnewbonetissueswasobserved.Attheendof8thweek,thereweremanynewlyformedbonematuretissues.Moreover,theareaofthelatterwassignificantlylargerthanthatoftheformer(P＜0.01),whileinthecontrolgrouptherewasnonewboneformation.Thetissue-engi-neeredbone,whichwasconstructedbycombiningzinc-sinteredbovinecancellousbonewithMSCs,hassatisfactoryosteogeniccapabilitiesinvivo.

简介：AIMTo在角膜的endothelial房间(CEC)并且到的增长上探索调节媒介的效果比较不同调节媒介(厘米)的效率.METHODSRatCEC，角膜的stromal房间(CSC)，骨头导出髓的endothelial祖先房间(BEPC)，并且骨头导出髓的间充质的干细胞(BMSC)被孤立并且在vitro有教养。厘米从CSC，BEPC，和BMSC被收集。CEC在不同文化媒介被栽培。房间形态学被记录，并且基因和蛋白质表示是为5d在厘米种的analyzed.RESULTSAfter，在每个试验性的组的CEC仍然保持多角形，在像鹅卵石的单层安排。Immunocytofluorescence揭示了Na+/K+-ATP,aquaporin的积极表示1(AQP1)，并且zonulaoccludens1(ZO-1)。把分析基于量的聚合酶链反应(qPCR)，在CSC厘米的Na+/K+-ATP表示是尤其是由1.3褶层的upregulated(±；0.036)(P<；0.05，n=3)。ZO-1的表示层次，神经原特定的enolase(NSE)，Vimentin，配对的homebox6(PAX6)，并且procollagen类型VIII(COL8A1)是尤其是在每个试验性的组的upregulated。每厘米在CEC增长上有积极效果，并且CSC厘米在proliferation.CONCLUSIONCSC厘米，BEPC厘米，和BMSC厘米上有最强壮的效果不仅刺激了CEC的增长，而且坚持说特征区分了为endothelial功能必要的显型。CSC厘米在CEC增长上有最著名的效果。

简介：Ithasbeendemonstratedthattbecriticalroleofbonemarrowstromalcells(HMSCs)istosustaintheselfrenewalofpluripotenthematopoieticstemcellsandmaintainthehomeostasisofbonemarrowhematopoiesismicroenvironment.BMSCprogenitorcandifferentiateintoseveralclementsincludingmacrophages,endothelialcells,fibroblastsandsomeothercells.Almostall

简介：AbstractBackground:Previous studies have reported that mitochondrial dysfunction participates in the pathological process of osteoarthritis (OA). However, studies that improve mitochondrial function are rare in OA. Mitochondrial transfer from mesenchymal stem cells (MSCs) to OA chondrocytes might be a cell-based therapy for the improvement of mitochondrial function to prevent cartilage degeneration. This study aimed to determine whether MSCs can donate mitochondria and protect the mitochondrial function and therefore reduce cartilage degeneration.Methods:Bone-marrow-derived mesenchymal stromal cells (BM-MSCs) were harvested from the marrow cavities of femurs and tibia in young rats. OA chondrocytes were gathered from the femoral and tibial plateau in old OA model rats. BM-MSCs and OA chondrocytes were co-cultured and mitochondrial transfer from BM-MSCs to chondrocytes was identified. Chondrocytes with mitochondria transferred from BM-MSCs were selected by fluorescence-activated cell sorting. Mitochondrial function of these cells, including mitochondrial membrane potential (Δψm), the activity of mitochondrial respiratory chain (MRC) enzymes, and adenosine triphosphate (ATP) content were quantified and compared to OA chondrocytes without mitochondrial transfer. Chondrocytes proliferation, apoptosis, and secretion ability were also analyzed between the two groups.Results:Mitochondrial transfer was found from BM-MSCs to OA chondrocytes. Chondrocytes with mitochondrial from MSCs (MSCs + OA group) showed increased mitochondrial membrane potential compared with OA chondrocytes without mitochondria transfer (OA group) (1.79 ± 0.19 vs. 0.71 ± 0.12, t = 10.42, P < 0.0001). The activity of MRC enzymes, including MRC complex I, II, III, and citrate synthase was also improved (P < 0.05). The content of ATP in MSCs + OA group was significantly higher than that in OA group (161.90 ± 13.49 vs. 87.62 ± 11.07 nmol/mg, t = 8.515, P < 0.0001). Meanwhile, we observed decreased cell apoptosis (7.09% ± 0.68% vs.15.89% ± 1.30%, t = 13.39, P < 0.0001) and increased relative secretion of type II collagen (2.01 ± 0.14 vs.1.06 ± 0.11, t = 9.141, P = 0.0008) and proteoglycan protein (2.08 ± 0.20 vs. 0.97 ± 0.12, t = 8.227, P = 0.0012) in MSCs + OA group, contrasted with OA group.Conclusions:Mitochondrial transfer from BM-MSCs provided protection for OA chondrocytes against mitochondrial dysfunction and degeneration through improving mitochondrial function, cell proliferation, and inhibiting apoptosis in chondrocytes. This finding may offer a new therapeutic direction for OA.

简介：BACKGROUND:Ithasbeendemonstratedthattransforminggrowthfactor-β(TGF-β)andbrain-derivedneurotrophicfactor(BDNF)caninducestemcelldifferentiationintoneuron-likecells.OBJECTIVE:ToinvestigatetheefficacyofTGF-βandBDNFatinducingthedifferentiationofadultratbonemarrowstromalcells(BMSCs)intoneuron-likecells,bothincombinationoralone.DESIGN,TIMEANDSETTING:AcomparativeobservationexperimentwasperformedattheDepartmentofOrthopedics,FirstAffiliatedHospitalofLiaoningMedicalUniversitybetweenOctober2007andJanuary2008.MATERIALS:TGF-βandBDNFwerepurchasedfromSigma,USA;mouseanti-ratneuronspecificenolase,neurofilamentandglialfibrillaryacidicproteinwerepurchasedfromBeijingHMHLBiochemLtd.,China.METHODS:BMSCswereisolatedfromratsaged4weeksandincubatedwithTGF-β(1μg/L)and/orBDNF(50μg/mL).MAINOUTCOMEMEASURES:Expressionofneuron-specificenolase,neurofilamentandglialfibrillaryacidicproteinweredeterminedbyimmunocytochemistry.RESULTS:BMSCsdifferentiatedintoneuron-likecellsfollowinginductionofTGF-βandBDNF,andexpressedbothneuron-specificenolaseandneurofilament.ThepercentofpositivecellswassignificantlygreaterinthecombinationgroupthanthoseinducedwithTGF-βorBDNFalone(P<0.01).CONCLUSION:TreatmentofBMSCswithacombinationofTGF-βandBDNFinduceddifferentiationintoneuron-likecells,withtheinductionbeingsignificantlygreaterthanwithTGF-βorBDNFalone.

简介：Objective:Toexaminetheeffectsofratmarrowstromalcells(rMSCs)ongeneexpressionoflocalbrain-derivedneurotrophicfactor(BDNF)andnervegrowthfactor(NGF)afterinjectionofrMSCsintoCisternMagnumofadultratssubjectedtotraumaticbraininjury(TBI).Results:GroupcelltransplantationhadhigherBDNFandNGFgeneexpressionsthanGroupsalinecontrolduringaperiodoflessthan3weeks(P<0.05).Conclusions:rMSCstransplantationviaCisternMagnuminratssubjectedtotraumaticbraininjurycanenhanceexpressionsoflocalbrainNGFandBDNFtoacertainextent.

简介：胃的胃肠的stromal肿瘤的stagesIandIII之间的差别主要取决于有丝分裂的数字。与TNM分类，在高有丝分裂的率的肿瘤的存在决定升级。许多研究在评估有丝分裂的数字暴露了不同计数技术。估计有丝分裂的率的一个国际标准化方法被需要。

简介：Objective:DiffuseLargeBCellLymphoma(DLBCL)isaheterogeneousgroupoftumorswithdifferentbiologicalandclinicalcharacteristicsthathavediverseclinicaloutcomesandresponsetotherapy.Stromal-1signatureoftumormicroenvironmentofDLBCLrepresentsextracellularmatrixdepositionandhistiocyticinfiltrate,whereasstromal-2representsangiogenesisthatcouldaffecttumorprogression.Methods:Theaimofthepresentstudyistoassessthesignificanceofstromal-1signatureusingSPARC-1andstromal-2signatureusingCD31expressionandthenfinallytoconstructbiologicprognosticmodel(BPM)in60casesofDLBCLviaimmunohistochemistry.Results:Microvesseldensity(P<0.05)andSPARCpercentageofexpression(P<0.001)werehigherinDLBCL,includinggerminalandnongerminalcases,comparedwithreactivefollicularhyperplasia.Highmicrovesseldensitywassignificantlyassociatedwithsplenicinvolvement(P=0.008),highmitoticcount(P=0.045),andpresenceofcapsularinvasion(P=0.035).PercentageofSPARCexpressionwassignificantlyassociatedwithsplenicinvolvement(P=0.03).ConstructingBPMshowedthat42cases(70%)wereoflowbiologicscore(0–1)and18cases(30%)wereofhighbiologicscore(2–3).LowBPMcasesshowedlessprobabilityforsplenicinvolvement(P=0.04)andahigherrateofcompleteresponsetotherapycomparedwithhighscorecases(P=0.08).Conclusions:TheDLBCLmicroenvironmentcouldmodulatetumorprogressionbehaviorsinceangiogenesisandSPARCpositivestromalcellspromotedisseminationbyassociationwithspleeninvolvementandcapsularinvasion.Biologicprognosticmodels,includingmodifiedBPM,whichconsideredcelloriginofDLBCLandstromalsignaturepathways,coulddetermineDLBCLprogressionandresponsetotherapy.

简介：Gastrointestinalstromaltumors(GISTs)occurmostfrequentlyinthestomach.DiagnosisofgastricGISTisnotalwaysclearbeforesurgery.Flexibleendoscopymaysuggestthenatureofthelesion(abulkytumorwithpreservedmucosa);however,biopsyisrarelydiagnostic.Therefore,diagnosticmedicationwithsafedrugsmayprovideafeasiblewayundersuchconditionsafteraninformedconsentisobtained.Basedontheexcellentefficacyofimatinibmesylate(IM)inthetreatmentofGIST,wesuccessfullyapplieditinthediagnosticmedicationoftwopatientswithclinicallysuspectedgastricstromaltumors.Inconclusion,thediagnosticmedicationwithIMcanbeanalternativeoptionforpatientswithsuspectedGISTthatcannotbeconfirmedpathologically.

简介：pluri有势力干细胞的能力为治疗长期、退化的疾病在新奇房间代替治疗学的开发保持大诺言修理干细胞在住的纸巾。然而，众多的报告证明甚至在一个自体同源的背景，那干细胞治疗触发淋巴细胞渗入和发炎。因此，要回答的一个重要问题是主人免疫系统怎么对嫁接自体同源的干细胞或allogeneous干细胞作出回应。在这简短评论，我们在这块地里在几个相关区域总结进步，包括一些我们的数据，在四节：(1)干细胞的immunogenicity；(2)禁止有免疫力的拒绝到allograft干细胞的策略；(3)对癌症干细胞的有免疫力的回答；并且(4)在有免疫力的规定的间充质的干细胞。我们这些和有免疫力的系统茎细胞相互影响的另外的方面上的理解的改进将极大地便于茎的发展为再生目的基于房间的治疗学。

简介：客观直到最近胃肠的基质肿瘤(大意)与另外的间充质的瘤被分开了；作为一个特殊实体分类。肿瘤房间的形态学；免疫有CD117的组织化学的调查结果在大意的病理学的诊断是关键的。最新发达的药imatinibmesylate(先前叫的STI571)为大意被证明有效。大意的区别；另外的间充质的肿瘤有大临床的意义，特别为位于直肠肛门的损害。作者寻找了北京大学的数据库的方法，为有肛门直肠的瘤的病人的肿瘤学的学校从1995年1月对待到2002年6月。有肛门直肠的间充质的肿瘤的12个病人的信息是镇定的。病人被重新估计；与临床的数据根据电流讨论了大意的标准；免疫组织化学的调查结果。结果六个病人(包括3男性)最后作为肛门直肠的大意被诊断。那些病人的中部的年龄是59.5年(27～69)。症状不是特定的。有平滑肌瘤或平滑肌肉瘤的原来的诊断的三个盒子实际上是大意。六肛门直肠的大意的一个总数被发现作为在一样的时期与肛门直肠的瘤包括大约1.06%病人。除CD117以外，CD34；vimentin也在这些病人的多数被表示。六个病人中的五个经历了其一在切除术前收到了neoadjuvant化疗的外科的切除术。结论肛门直肠的大意应该用当前的诊断标准被看作一个特殊实体。外科的切除术仍然是主要治疗学的策略。Neoadjuvantimatinibmesylate可能在括约肌圆材操作是有用的；为这些病人的生命的质量的改进。

简介：Inordertofurtherpromotethestandardizationofdiagnosisandtreatmentofgastrointestinalstromaltumor(GIST)inChina,themembersofChineseSocietyofClinicalOncology(CSCO)ExpertCommitteeonGISTthoroughlydiscussedthekeycontentsoftheconsensusguidelines,andvotedonthecontroversialissue.Infinal,theChineseconsensusguidelinesforthediagnosisandmanagementofGIST(2017edition)wasformedonthebasisof2013editionconsensusguidelines,whichisherebyannounced.Theconsensusincludedthepathologicaldiagnosis,recurrenceriskclassificationevaluation,targetedagenttherapy,surgeryandprinciplesofsurveillanceofGIST.

简介：与他们在文化经历无限的自强并且在身体区分进所有房间类型的能力，人的胚胎的干细胞(hESCs)为治疗保持大潜力当前不治之症。为针的绳索损害和有斑点的退化的二基于hESC的房间治疗被推进了进人的临床的试用。尽管有这快速的进步，基于hESC的房间治疗的一关键挑战是由接受者的导出hESC的房间的allogeneic免疫者拒绝。这个问题能被病人特定的体的房间的原子reprogramming被最近的突破与定义因素在导致的pluripotent干细胞(iPSCs)的技术减轻它能为房间治疗成为自体同源的房间的可更新的来源。然而，揭示反常epigenetics，genomic稳定性和iPSCs的immunogenicity的最近的研究在基于iPSC的治疗上提起了安全担心。与iPSC衍生物的immunogenicity有关的最近的调查结果将在这评论被总结。