简介：Sincethestartofthereformandopeningdrive,foreigntradeandeconomiccooperationinShaanxiProvincehasmadesignificantprogress.Bytheendof1995,theprovincehadapprovedtheimplementationof2,313itemsutilizingforeigninvestment,withtotalinvestmentvalueofUS＄6.771billion,contractualforeigninvestmentvalueofUS＄4.94billion,actualutilizationofforeigninvestmentofUS＄2.118billion,accountingfor42.9percentofthecontractualforeigninvestmentvalue.InJanuary-April1996,theprovinceapproved106itemsofforeigndirectinvestment,withtotalinvestmentofUS＄308million,contractualforeigninvestmentofUS＄220millionandactualutilizationofforeigninvestmentofUS＄116million.

简介：RE-containingfertilizer,developedbytheStateAgriculturalAssociationincollaborationwitharesearchgroupofBeijingNon-FerrousMetalResearchIns-titute,hasbornefruitsinChina’sagri-culture.Theeffectivenessofthisfer-tilizer,calledNongle,isstriking.In1986,farmersinSouthChina’sGuangxiZhuangAutonomousRegionused

简介：TheChinesegovernmentpaysparticularattentiontointernationalexchangeandcooperationinhumanrights.TheNPCStandingCommitteeapprovedtheInternationalCovenantonEconomic,SocialandCulturalRightsonFebruary28,2001anddeliveredthedocumentofratificationtotheUNSecretaryGeneralonMarch27,2001.TheChinesegovernmentopposesterrorismofalldescriptionsandpaysattentiontointernationalcooperationinsuppressingterrorism.AsearlyasbeforetheSeptember11terroristattacksontheUnitedStates,theChinesegov-

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简介：DistinguishedGuests,LadiesandGentlemen,DearFriends,Goodmorning.Thankstothejointeffortsofallparticipants,theFirstShanghaiCooperationOrganizationPeople＇sForumhascompleteditsagendaandnowweareholdingtheclosingsessionhere.Firstofall,onbehalfoftheChinaNGONetworkforInternationalExchanges（CNIE）,Iwouldliketopaytributeandextendourthankstoallthedistinguishedguestsandparticipantscomingtotheforum.

简介：ItisobviousthatSino-JapaneserelationsareimportantlybothtoChinaandtoJapan.Nevertheless,therealityof"hoteconomicrelationsvs.coldpoliticalrelations"betweenthetwocountriespuzzlespeoplewhoshowdeepconcernforSino-Japaneserelations:AretheinherentfeaturesofSino-Japaneserelationsthecauseofthephenomenon?Isthegapbetweenaspirationandactionthecauseofit?Orbotharethecauses?Theansweristhere,butexplorationneedstobemade.

简介：TheStateCouncilinformationOfficeunveiledthenationalhumanRightsactionPlan(2012-2015)(hereinafterreferredtoastheactionPlan)onJune11,drawingwideattention,bothdomesticallyandinternationally.WangChen,ministeroftheStateCouncilinformationOffice,answeredquestionsconcerningChina'sformulationoftheactionPlaninanexclusiveinterviewwiththeXinhuanewsagency.Thefollowingisthetranslatedversionofthefulltextoftheinterview:Xinhua:TheChinesegovernmentintroducedthe

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简介：Paralysisfollowingspinalcordinjury(SCI)isduetofailureofaxonalregeneration.Itisbelievedthatthecapacitiesofneuronstoregrowtheiraxonsareduepartlytotheirintrinsiccharacteristics,whichinturnaregreatlyinfluencedbyseveraltypesofinhibitorymoleculesthatarepresent,orevenincreasedintheextracellularenvironmentoftheinjuredspinalcord.Manyoftheseinhibitorymoleculeshavebeenstudiedextensivelyinrecentyears.IthasbeensuggestedthatthesmallGTPaseRhoAisanintracellularconvergencepointforsignalingbytheseextracellularinhibitorymolecules,butduetothecomplexityofthecentralnervoussystem(CNS)inmammals,andthelimitationofpharmacologicaltools,thespecificrolesofRhoAareunclear.ByexploitingtheanatomicalandtechnicaladvantagesofthelampreyCNS,werecentlydemonstratedthatRhoAknockdownpromotestrueaxonregenerationthroughthelesionsiteafterSCI.Inaddition,wefoundthatRhoAknockdownprotectsthelarge,identifiedreticulospinalneuronsfromapoptosisaftertheiraxonswereaxotomizedinspinalcord.Therefore,manipulationoftheRhoAsignalingpathwaymaybeanimportantapproachinthedevelopmentoftreatmentsthatarebothneuroprotectiveandaxonregeneration-promoting,toenhancefunctionalrecoveryafterSCI.

简介：RolesofKeap1-Nrf2pathwayinbrain:NeuronalsurvivalandneurogenesisareimpairedinneurodegenerativediseasessuchasParkinson’sdiseaseandAlzheimer’sdisease(Winneretal.,2011).Geneticup-regulationofgrowthfactorsenhancedneuronalsurvivalandneurogenesis,improvedneuronalfunctionsandhalteddiseaseprogressioninanimalmodelsofAlzheimer’sdisease

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简介：AbstractObjective:Capsaicin (CPS) is a major component of the red pepper, and its anti-tumor property has been confirmed. However, the underlying mechanism of this anti-tumor effect has not been fully clarified, so we conducted this study to evaluate the role of mitochondrial fission and subsequent mitochondrial dysfunction in CPS-induced apoptosis of melanoma cells.Methods:Two melanoma cell lines and melanocytes were treated with CPS alone or in combination with ruthenium red (a transient receptor potential vanilloid 1 [TRPV] antagonist), Z-VAD-FMK (a pan-caspase inhibitor), or N-acetyl-L-cysteine (an antioxidant). Cell vitality was tested using a cell counting kit-8 assay. The expression levels of related proteins were examined by Western blotting. Apoptosis, intracellular reactive oxygen species, mitochondrial membrane potential, adenosine triphosphate levels, and mitochondrial dynamics were analyzed by flow cytometry, luminometry, and confocal laser microscopy, respectively, and compared between groups.Results:CPS treatment significantly inhibited the vitality of melanoma cells (For A2058 cells: 0 vs. 120 μmol/L: [100.00% ± 0%] vs. [51.02% ± 6.40%], P < 0.05; For WM35 cells: 0 vs. 120 μmol/L: [100.00% ± 0%] vs. [51.80% ± 3.45%], P < 0.05) but exerted less impact on normal melanocytes. CPS promoted melanoma cell apoptosis through TRPV channels and the caspase cascade. CPS treatment then led to TRPV channel-dependent mitochondrial dysfunction with an increase in reactive oxygen species generation (For A2058 cells: CPS vs. CPS+RR: [2.34 ± 0.30] vs. [1.34 ± 0.12], P < 0.05; For WM35 cells: CPS vs. CPS+RR: [2.25 ± 0.25] vs. [1.65 ± 0.13], P < 0.05), dissipation of the mitochondrial membrane potential (Control vs. CPS: [1.00 ± 0] vs. [0.61 ± 0.08], P < 0.05), and adenosine triphosphate reduction (P < 0.05). In addition, reactive oxygen species generation contributed to CPS-induced melanoma cell apoptosis. Mitochondrial fission was subsequently proved to connect CPS treatment to mitochondrial dysfunction, which was also TRPV channel-dependent, thereby inducing melanoma cell apoptosis.Conclusion:Our study highlights the role of mitochondrial fission and its related mitochondrial dysfunction in mediating the pro-apoptotic effect of CPS in melanoma. These findings deepen our understanding of the mechanisms underlying the anti-tumor activity of CPS and indicate the clinical relevancy of extending the use of this agent for cancer therapy.

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简介：T助手2(Th2)极化是在过敏疾病的一个主要病理学的特征；它的病原学充分没被理解。这研究试图阐明在抗原特定的Th2的开始的微生物引起的导出产品的小肽的辅助效果极化。在这研究，有长期的rhinosinusitis(CRS)和食物过敏症(FA)的病人的临床的调查被执行。StaphylococcalenterotoxinB(SEB)导出小肽(Ssps)在人的凳子摘录被检验。Ssp/antigen的形成使内收在蛋白质蛋白质联合试金被测试。骨头导出髓的树枝状的房间(BMDC)被采用测试Ssp/ovalbumin(卵)的角色在树枝状的房间(DC)使内收成熟。一个老鼠模型被开发测试Ssp/OVA的角色在肠在Th2极化的开始使内收。结果显示出那54(18.2%；)有FA的病人与SEB+CRS在296个病人之中被诊断；仅仅八(2.9%；)FA病人与SEB−CRS在272个病人之中被识别。Ssps与SEB−CRS与SEB+CRS从FA病人在凳子蛋白质摘录，然而并非在那些被检测。Ssp/OVA使内收导致了DC成熟，加快了DC移植，在地区性的淋巴节点激活CD4+T房间并且导致了在本地织物的扭曲的Th2极化。我们断定有SEB+CRS的病人对受不了FA敏感。SEB能在胃肠的道被降级到Ssps。Ssps能绑macromolecular抗原形成使内收在本地织物支持抗原特定的Th2极化和发炎的抗原和正式就职的antigenicity。

简介：ThemodernizationofstategovernanceandinnovationingoverningmeasureswillstrengthentheprotectionofhumanrightsinChina,includingcivilandpoliticalrights.Firstly,legalcontroloverpublicpowerwillreducearbitraryrestrictionsoncivilrights.Secondly,publicparticipationinpolicy-makingwillprovidemoreopportunitiesforcitizenstoexercisetheirpoliticalrights.Thirdly,governingbylawwillbetterguaranteeequalprotectionoflawforallpeople.Fourthly,aneffectiveaccountabilitymechanismwillreinforcepeople’srightofsupervision.Lastly,innovationingoverningmeasureswillhelpidentifyandsatisfycitizens’demands.

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简介：EditorialDepartmentAttheinvitationofChineseAssociationforInternationalUnderstanding（CAFIU）,a7-memberdelegationofIndianDelhiStudyGroup（DSG）headedbyMr.AshokGarg,Vice-PresidentofDSG,visitedBeijing,ShanghaiandNanjingfromMay18to24.InBeijing,Mr.LuoHaocai,Vice-ChairmanoftheChinesePeople＇sPoliticalConsultativeConference（CPPCC）andVice-PresidentofCAFIU,