简介:TheobjectiveofthisstudyistoexploreapotentiallyeffectivetrainingmethodforthehospitalprofessionalstoeducatedrugusersandtoenhancetheirknowledgeofHIVinfection.Onehundredandsixtyonesubjects,whocamefrom13differentprovincesandwereadmittedinadrugreliefhospitalinBeijing,wererecruitedforthisstudy.Theaverageageofthesesubjectswas35.21±6.24yearold.Theaveragenumbersofyearsfordrugaddictionwere7years,andtheaveragenumbersofdrugrelieftreatmentreceivedinthepastwas5.5times.ThelevelofAIDSknowledgeofthesesubjects,includingpathogenicfactors,sourceofinfection,routeoftransmissionandpreventivemeasures,wereevaluatedbeforeandafterreceivingtheAIDSeducationaltrainingtothesedrugusers.Ourresultsshowedthattherewasastatisticallysignificantincrease(P<0.01)intheknowledgeofHIVinfectionandpreventionamongthesesubjects.PositiveattitudeandbehavioraltendenciestowardHIVpreventionwerealsoimproved.Therefore,itisimperativeforthemedicalprofessionalstoincorporateAIDSeducationintodrugrelieftreatmenttoachievethemaximumeffectontheknowledgeofAIDSandimprovementofpositiveattitudesandbehaviorstowardHIVpreventionamongdrugusers.
简介:Drugdevelopmentinoncologyisundergoingasubstantialshiftnowadays.Thedriversforthisaremulti-factorial.Ontheoneside,drugdevelopmentisperformedmorerationallythanever,profitingfromthescientificadvancesinmolecularbiologyingeneralandtheelucidationofthevarious'omes'fromgenometometabolomeinparticular.Ontheotherside,itisbasedonenormoustechnologicalprogress,e.g.,inthefieldofgenome
简介:INTRODUCTIONSincetheirintroductioninmid-1980s,polyamidoamide(PAMAM)dendrimershaveattractedconsiderableattentionbecauseoftheiruniquestructuresandproperties.Accordingtopreliminarystudiesinanimals,PAMAMdendrimersarenon-immunogenic,verylowinvivotoxicityandcanbeexcretedbyurineandfeces.
简介:AnewclassofcrosslinkingpolyphosphatesweresynthesizedandcharacterizedbyIR^1HNMR,^31PNMRspectroscopyaswellaselementalanalysis.InvitrodegradationofthepolyphosphatesobtainedandthereleaseofantineoplasticdrugMethotrexate(MTX)andcontraceptiveLevonorgestrel(LNG)byusingthesepolymersasmatrixwerestudied.ZeroorderreleaseratewasobservedinthecaseofLNGrelease.
简介:抑郁症是目前对个人、家庭、社会都具有较大危害性的一种不可忽视的亚健康疾病。WHO估计全世界忧郁症患者有1.2-2亿。其中已有2000多万人使用抗忧郁药。现代医学指出,忧郁症是由血清素、多巴胺、去甲肾上腺素、乙酰胆碱和γ氨基丁酸5种神经传导素失调引起脑部化学结构发生改变所致。中医学认为是郁怒、思虑、悲哀、忧愁等七情所伤,导致了肝失疏泄,脾失运化,心神失常,阴阳失衡,气血失调。忧郁症具有”四高一低”的特点:即高发、高复发率、高致残、高负担、就诊率及识别率低。本文重点讨论了饮食疗法、运动疗法、音乐疗法、“移情易性”的精神治疗、品茗解郁清心乐生五种非药物疗法。以期改善忧郁症患者脑部的化学结构。克服抗忧郁药的副作用,从而减轻临床症状。
简介:Thisworkaimstoinvestigatetheeffectsofdosingregimentsondrugdeliveryinsolidtumorsandtovalidatethemwithexperimentsonrats.Thelumpedparametermodelsofpharmacokineticsandofdrugdeliveryintumorweredevelopedtosimulatetimecoursesofaveragedrugconcentration(Ct)oftumorinterstitiumintwotypesofdosingregiments(i.e.,single-shotandtriple-shotones).Thetworegimentswereperformedviaantitumordrug,hydroxycamptothecin(HCPT),onrats,tomeasurethedrugconcentrationinthetumor.Thesimulationsofthedrugconcentrationinthetumorofthetwodosingregimentswereconductedandcomparedwiththeexperimentaldataonrats.Thecoefficientsinthemodelswereinvestigated.Itisconcludedthatthetriple-shotmethodismoreeffectivethanthatofsingle-shotinjection.Thepresentlumped-parametermodelisquantitativelycompetentfordrugdeliveryinsolidtumor.
简介:摘要目的探究心理疗法联合药物疗法在变应性鼻炎临床治疗中的应用情况。方法选择我院2014年1月-2015年12月收治的120例变应性鼻炎患者,根据患者治疗方法的不同分为对照组和观察组,比较两组患者的临床治疗及院外治疗依从性。结果对照组患者的治疗总有效率为63.33%,观察组总有效率81.67%,观察组患者的治疗总有效率明显高于对照组患者,且存在显著性差异(P<0.05),具有统计学意义;出院12个月后,观察组患者的院外治疗依从性显著高于对照组患者(P<0.05),具有统计学意义。结论心理疗法联合药物疗法治疗变应性鼻炎疗效确切,在药物治疗基础上对患者进行心理指导和健康教育,缓解心理紊乱因素对病情的影响,通过调节情绪改善机体内分泌系统和神经系统,提高患者的对疾病和治疗情况的认知水平,提高治疗配合能力,值得在临床上推广应用。
简介:AlatticeBoltzmannnumericalmodelingmethodwasdevelopedtopredictskinconcentrationaftertopicalapplicationofadrugontheskin.ThemethodisbasedonD2Q9latticespacesassociatedwiththeBhatnagar-Gross-Krook(BGK)collisiontermtosolvetheconvection-diffusionequation(CDE).Asimulationwascarriedoutindifferentrangesofthevalueofbound,whichisrelatedtoskincapillaryclearanceandthevolumeofdiffusionduringapercutaneousabsorptionprocess.Whenatypicaldrugisusedontheskin,thevalueofcorrespondstotheamountofdrugabsorbedbythebloodandtheabsorptionofthedrugaddedtotheskin.Theeffectofwasstudiedforwhentheregionofskincontactisalinesegmentontheskinsurface.
简介:Colorectalcancer(CRC)isthethirdmostcommoncancerdiagnosedworldwideinhumanbeings.Surgery,chemotherapy,radiotherapyandtargetedtherapiesaretheconventionalfourapproacheswhicharecurrentlyusedforthetreatmentofCRC.Thesitespecificdeliveryofchemotherapeuticstotheirsiteofactionwouldincreaseeffectivenesswithreducingsideeffects.Targetedoraldrugdeliverysystemsbasedonpolysaccharidesarebeinginvestigatedtotargetanddeliverchemotherapeuticandchemopreventiveagentsdirectlytocolonandrectum.Site-specificdrugdeliverytocolonincreasesitsconcentrationatthetargetsite,andthusrequiresalowerdoseandhenceabridgedsideeffects.Somenoveltherapiesarealsobrieflydiscussedinarticlesuchasreceptor(epidermalgrowthfactorreceptor,folatereceptor,wheatgermagglutinin,VEGFreceptor,hyaluronicacidreceptor)basedtargetingtherapy;colontargetedproapoptoticanticancerdrugdeliverysystem,genetherapy.EventhoughgoodtreatmentoptionsareavailableforCRC,theultimatetherapeuticapproachistoaverttheincidenceofCRC.ItwasalsofoundthatCRCscouldbepreventedbydietandnutritionsuchascalcium,vitaminD,curcumin,quercetinandfishoilsupplements.ImmunotherapyandvaccinationareusednowadayswhichareshowingbetterresultsagainstCRC.