简介:ThirtyWistarratswererandomlyandevenlydividedintocontrolgroup,cerebralischemiagroupandischemia+electroacupuncture(EA)group.Thebilateralcommoncarotidarterieswereoccludedtoinduceacutecerebralischemia.Nitricoxide(NO)andendothelin(ET)contentsinthecerebraltissuesandbloodweremeasuredundernormalcondition,immediatelyafterischemiaandfollowingEA.ResultsshowedthatafteracutecerebralischemiaNOandETcontentsinthecerebraltissuesincreasedsignificantly(P<0.01)whileserumETincreasedandserumNOloweredobviously(P<0.05).FollowingEAofBaihui(GV20)andDazhui(GV14),bothNOandETincerebraltissuesandserumturnedtonormalbasically.ItshowedthatEAcouldprotectthecerebraltissuesfrominjuryinducedbyischemia,NOandETmightparticipateinthemodulationprocessofEA.
简介:Objective:Toinvestigatetheunderlyingneurobiologicalmechanismoftheprotectiveeffectofelectroacupuncture(EA)duringcerebralischemia-reperfusion(CI-R).Methods:Inthefirstpartofthestudy,15SDratswereevenlyrandomizedintocontrolgroup,CI-R-48hmodelgroupandCI-R-48h+EAgroup.ThecorticalapoptosisandexpressionofBcl-2andBaxproteinsineachgroupweredetectedbyflowcytometer(FCM).Inthesecondpartofthestudy,75SDratswereevenlyrandomizedintocontrol,CI-R-3min,CI-R-3min+EA,CI-R-48handCI-R-48h+EAgroups.Corticalnorepinephrine(NE)concentrationwasdetectedbyfluorescencespectrometer.CI-Rmodelwasestablishedbyocclusionofthebilateralcommoncarotidarteriesandreperfusion.EA(4~16Hz,1~3V)wasappliedafterreperfusionrespectively.Results:Inthefirstpartofthisstudy,resultsindicatedthatthenumberoftheapoptoticneuronsandtheapoptosisrateofCI-R-48hgroupweresignificantlyhigherthanthoseofcontrolgroup;whilecomparisonbetweenCI-R-48h+EAandCI-R-48hgroupsshowedthatthenumberoftheapoptoticneuronsandtheapoptosisrateoftheformergroupweresignificantlylowerthanthoseofthelatergroup(P<0.05).Incomparisonwithcontrolgroup,afterCI-48h,Baxexpressionwasup-regulatedsignificantlyandBcl-2down-regulatedmarkedly(P<0.05).ComparisonbetweenCI-R-48handCI-R-48h+EAgroupindicatedthatBaxexpressionofthelatergroupwassignificantlylowerthanthatoftheformergroup,whileBcl-2expressionofCI-R-48h+EAgroupwassignificantlyhigherthanthatofCI-R-48hgroup(P<0.05),suggestingthatEAcouldreverseCIinducedreactionsofthesetwoindexes.Inthesecondpartofthestudy,incomparisonwithcontrolgroup,NEconcentrationincerebralcortexofCI-R-3mingroupincreasedsignificantly(P<0.05);whileNEcontentofCI-R-3min+EAgroupwassignificantlylowerthanthatofCI-R-3mingroup(P<0.05).NosignificantdifferencewasfoundbetweenCI-R-3mingroupandcontrolgroupincorticalNEl
简介:Objective:Toobservetheeffectofacupunctureonimagesinautismchildren.Methods:Atotalof27casesofautismchildrenweresubjectedintothisstudy.ByusingaSPECT,thecerebralimageswerecollectedbeforeandafteracupuncturetreatmentandanalyzedaccordingtotherecommendedmethodsinforassessingthestateofbloodflow,radioactivityquantitydistributionandradioactivitycountinbilateralhemispheres.'JIN'sthree-needling'wasemployed.Theacupuncturetreatmentwasgivenonceeveryotherday,with4monthsbeingatherapeuticcourseandanintervalofonemonthbetweentwocourses.Results:Afteracupuncturetreatment,ofthe22cases,20hadremarkableimprovementand2hadimprovementincerebralbloodflow,withthetotaleffectiverateofimprovingcerebralbloodflowbeing90.8%.Beforethetreatmentthereweresignificantdifferencesbetweentheleftandrightcerebrum(P<0.001),andbetweentheleftandrightfrontallobesinradioactiveareas(P<0.01);however,aftertreatment,nodifferenceswerefoundbetweenthem(P>0.05).Aftertreatment,theradioactivitycountinthewholebraindecreasedsignificantlyincomparisonwiththatofpretreatment(P<0.01).Itindicatestheimprovementofcerebralbloodflowandcellularmetabolismafterthetreatment.Conclusion:Acupumctureconsignificantlyimprovecerebralbloodflowinautismchildren.
简介:Objectives:Toexploretheeffectofacupunctureoncerebralinfarctioninratsandtotryprovidingsomeexperimentalparametersforclinicalpractice.Methods:27healthyWistarratswererandomlydividedintopseudo-operation(n=10),model(n=8)andacupuncture(n=9)groups.Neuro-functionaldefectscoring,apoptosisofsinglebrainsliceandthenumberofbcl-2immuno-reaction(IR)-positiveneuronsinCA1areaofthehippocampuswereusedastheindexestoinvestigatethepossiblemechanismsofacupunctureof'NieSanZhen'(needlingthreeacupointsinthetemporalregion)and'SiShenZhen'(needlingfouracupointsintheocciputregion)intreatingratswithcerebralinfarction.Results:Thereexistedsignificantdifferencesbetweenacupuncturegroupandmodelgroupinimprovingneurologicfunctionalactivities,inhibitingapoptosisofthebraincellsandincreasingbcl-2IR-positiveneuronsinthehippocampalCA1area(P<0.01).Conclusion:Acupuncturetherapycanimprovecerebralinfarctionintheratbysuppressingapoptosisandup-regulationofthebcl-2IR-positiveneuronexpression.
简介:Objective:Toimprovethediagnosisandtreatmentofseverecerebralfatembolism(SCFE).Methods:ThedataofninepatientswithSCFEwereretrospectivelyanalyzed.Themanifestationsofthecentralnervesystem,respiratorysystemandhemorrhagewererecorded,atthesametime,accessoryexaminationincludingarterialoxygen,fatmacroglobulesinvenousbloodandimageexaminationwasadapted.Thepatientsweretreatedwithexopexy,pharmocotherapyandoxygentherapy.Results:Twooftheninepatientsdiedofseverecomplications,theothersevenrecoveredwithoutseveresequela.Conclusions:GurdstandardshouldbeimprovedforearlydiagnosisofSCFE.Ifsverecomplicationscanbeprevented,patientswhoreceiveearlytreatmentwillhavefavourableprognosis.
简介:Objective:Toobservethetherapeuticeffectofoculo-acupuncturetherapyinthetreatmentofcerebralinfarctioninducedhemiplegia.Methods:58casesofstrokepatientswererandomlydividedintotreatmentgroup(n=30)andcontrolgroup(n=28).Intreatmentgroup,onthebasisofmedicationplusrehabilitationtreatment,patientsvoluntarilyacceptedoculo-acupuncturetherapy(acupunctureofUpper-JiaoAreaandLower-JiaoArea).Incontrolgroup,patientsonlyacceptedmedicationandrehabilitationtreatment.ThetherapeuticeffectwasevaluatedwithBrunstrom's6-stagesAssessingMethod.Results:After24sessionsoftreatment,theratiosofthediseasedlimbsreachingstageⅥandmoreinfunctionalactivityinthepatientsoftreatmentgroupincreasedfrom16.7%(upper-limb)and20.0%(lower-limb)beforetreatmentto70.0%and90.0%respectively;whileincontrolgroup,thoseratiosoftheupperandlowerlimbsincreasedfrom10.7%and28.6%beforetreatmentto39.2%and60.7%separately.Therewasasignificantdifferencebetweentwogroupsinthetherapeuticeffect(P<0.05).Conclusion:Oculo-acupunctureplusmedicationissuperiortosimplemedicationtreatmentinimprovingfunctionalactivityofthehemiplegiclimbs.
简介:Objective:TodiscussthemechanismofcerebralvesselspasmcausedbyconcussionandtheeffectofNimodipineonconcussion.Methods:Atotalof224patientswhoweretreatedfromMarch1995toOctober1999weredividedintotwogroupsrandomly,ie.Nimodipinegroup(113cases)andcontrolgroup(11cases).Middlecerebralartery(MCA),basilarartery(BA)andtheaveragepeakforwardvelocityofcerebralbloodflowwereobservedbycolorthree-dimensionaltranscranialDoppler(3D-TCD)within24hoursafteradmissionandattheendof3-6daysoftreatment.Cerbralbloodflowchanges,characteristicsandtreatmenteffectwereanalyzedanddeterminedbyclinicalmainsymptomdisappearancerate.Results:Inconcussion,cerebralbloodflowwasdividedinto3phases:cerebralbloodflowlowinfusiondilationphase,cerebralbloodvesselspasmphaseandcerebralbloodflowrecoveryphase.IntheNimodipinegroup,clinicalmainsymptomdisappearanceratewashigherthanthatinthecontrolgroupinthecerebralspasmandrecoveryphaseswithasignificantdifference(P<0.01).Conclusions:Cerebralvesselspasm,hypoxiaandischemialesionarethemainpathologicalchanges.Whethercerebraldysfunctionisreversibleornotismainlydeterminedbyspasmtimeofcerebralbloodvessel.Nimodipinehasagoodeffectonreleasingspasmanddiminishingthecerebralbloodfolwvelicity.Itnotonlyimprovescurativeeffectonconcussion,butalsoreducesandpreventsconcussionsequelae.Hence,concussionpatientswhohavecerebralspasmconfirmedby3D-TCDshouldbegivenNimodipineroutinelyandearly.
简介:ThetherapyofUBI(TheUltravioletirradiationoxygenateBloodItself-transfu-sion)isusedtotreat69casesofthepatientswithcerebralinfarctionwhichareallprovedtobecerebralinfarctionbythescanningofCT.TheeffectsofUBIonthenailfoldmicrocirculationofthepatientswerestudiedwith“WeightedMultipleScoreofthenailfoldmicrocirculation”workedoutbythemicrocirculationalspecialgroupP.L.A.Comparedwiththesameagedhealthyperson,theMultiplescoreofthenail
简介:Thedynamicsindexes,playinganimportantroleinthecerebralcirculation,willbechangedsignificantlycomparedwiththeirnormalrangeinmanycerebrovasculardisease.ThegeometricalparametersofcerebrovascularmaybedetectedbyDSAorMRAscan,butthehemodynamicparameters,suchas,bloodflow,arteryresistanceandcompliancemustbecalculatedbybuildinghemodynamicsmodel.Thecerebralcircularsystemthathasfourentrancesforbloodflow(twocarotidandtwovertebralarteries)andthreecommunicatingarteriesismuchdifferentfromthesystematicststemwhichhasonlyoneentrance,ic.,theaortic.Thepurposeofthisstudyistosetupahemodynamicsmodelwithlumpedparameterstodescribethecerebralcirculation.Fromthismodel,wegetitsgoverningequationsandpresentanewmethodtocalculatethehemodynamicsindexesinclinicalapplication.
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简介:Inthepresentpaper,theauthorsreviewrecentadvancesinclinicalandexperimentalstudiesonacupuncturetreatmentofcerebralhemorrhage(CH).Regardingclinicalstudies,theresuscitation-inducingneedlingmaneuver,andmainpointsofShuigou(水沟GV26),Baihui(百会GV20)andscalp-pointsMotorArea(MS6),SensoryArea(MS7),etc.areofteninvolved.Concerningexperimentalstudies,theunderlyingmechanismsofacupunctureofGV-26+'Neiguan'(内关PC6),GV-20,GV-26+GV-20,etc.inimprovingacuteCHareintroduced.Inaword,acupuncturetherapyworkswellinimprovingclinicalsymptomsandsignsofCHpatients,andacupuncturestimulationinducedameiliorationofcerebralbloodflow,favorablemodulationofsomebioactivesubstancesasexcitatoryandinhibitoryaminoacids,endothelin,CGRP,heatshockprotein70,etc.andneuro-endocrine-immunenetworkmaycontributetotheeffectofacupunctureonCH.Inaddition,acupuncturecombinedwithmedicineandearlierapplicationofacupuncturetherapyintheacutestageofCHarerecommendedinclinicalpractice.
简介:Objective:Toobservetheeffectofelectroacupuncture(EA)onsynapticstructureofhippocampalnervefeltsandsynaptophysin(SYN)expressioninratswithcerebralischernicinjury.Methods:SixtyWistarratswererandomizedintoshah-operationgroup,cerebralischemia(CI)groupandEAgroup,eachofwhichwasfurtherdividedinto1week(W)and5Wsubgroups.Clinjurymodelwasestablishedbyocclusionofthebilateralcomrnoncarotidarter-ies.“Baihui”(百会GV20),“Dazhui”(大椎GV14),“Renzhong”(人中GV26)and“Guenyuan”(关元CV4)werepuncturedandstimulatedelectrically.Thebraintissuesectionscontaininghippocampusregionwerestainedwithirnrrunohistochernicaltechniqueandobservedunderlightmicroscopeandtransmissionelectronicmicroscope.Results:AfterCI,theischemicinjuryasdegenerationofthepresynapsecompositions,decreaseofthesynapticnumeraldensity,andlowexpressionofSYNwereobservedinhippocampalCA1area.Bythe5^thweekafterCI,theneonatalsynapsesofCIandEAgroupsappeared,andSYNexpressionwasupregulated.InEAgroup,therecoveryofthenumeraldensityofsynapseswasespeciallynoticeable,being93.8%ofthatofsham-operationgroupandsignificantlyhigherthanthatinCIgroup(P<0.01).Comparedwithsham-operationgroup,thecalibratedopticaldensity(COD)valuesofSYNincreasedto70%inCIgroup,and93.3%inEAgroup,andCODvalueinEAgroupwassignificantlyhigherthanthatinCIgroup(P<0.01).Conclusion,EAcanfunctioninpromotingsynapticregenerationandenhancingandperfectingtheactionsofthereconstructedsynapsesinhippocampalCA1areainCIrats.
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简介:BACKGROUND:Previousstudiesreportedthatfrontal-temporal-parietal-occipitalpathologicalchangesanddiseasedrangeintherightcerbralhemispherewerecorrelatedwithneglect.Butstudiesonthecorrelationofneglectwithdiseasedregionandareainpatientswhosufferfrominitialattackofsinglefocusofcerebralinfarction(CI)inleftandrightcerebralhemispheresarefew.OBJECTIVE:ToobservethestatusofneglectinpatientswhosufferfromsinglefocusofCIincerebralhemisphereandanalyzethecorrelationofneglectwithdiseasedregionandareaofCI.DESIGN:CaseanalysisSETTING:TreatmentCenterforCardiocerebrovascularDisease,SecondHospitalofXiamencity;DepartmentofNeurology,FirstHospitalAffiliatedtoBaotouMedicalCollege.PARTICIPANTS:AlltheCIpatientshospitalizedintheDepartmentofNeurology.FirstHospitalAffiliatedtoBaotouMedicalCollegefromJune1998toMay2001wereretrieved.Inclusivecriteria:①PatientswhosufferedfrominitialattackofCI.whichwasconfirmedbyskullCTorMRIwithin24hoursafteronsetandpresentedsinglefocusincerebralhemisphere.②beconsciousandcouldcooperateintheexamination.③didnotreceiveformaleducation,butcoulddoaccountsandsomesimplewritingandreading.④Patientswithhomonymoushemianopiawereexcludedthroughtheexaminationofperimeter.⑤Informedconsentswereobtainedfromallthepatients.Among67patientswhomettheinclusivecriteria.33sufferedfromCIintheleftcerebralhemisphereand34intherightcerebralhemisphere.METHODS:①PatientsreceivedneglectsupplementexaminationandChineseaphasiaexaminationwithin2.5to3monthsaftertheattackofCI.Thediagnosticcriteriaofneglectinthetestsoflinecancellation.1inebisectionandcopyingthefigureswereasfollows:InthelinecancellationtestbasedonthemethodofAlbert.patientswhocouldnotcanceloneormorelineswereregardedasabnormal.InthelinebisectiontestbasedonthemethodofPeter.patientswholeftdeviated1.16%